血液科住院患者医院感染影响因素分析  

Analysis of influencing factors for hospital infections in inpatients in hematology department

作　　者：郭淑利[1] 田红旗[1] 王慧睿[1] 

机构地区：[1]郑州大学附属洛阳市中心医院血液内科,河南洛阳471008

出　　处：《中华医院感染学杂志》2015年第4期862-864,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅重点基金资助项目(20130417)

摘　　要：目的探讨血液科患者医院感染发生率及引起医院感染的相关高危因素,以期为医院感染的预防控制提供参考。方法回顾性分析2012年1月-2013年6月538例血液病患者临床资料,分析医院感染发生率及相关危险因素,数据采用SPSS16.0软件进行统计分析,多因素分析采用非条件多因素logistic回归分析。结果 538例患者发生医院感染76例、93例次,感染率为14.13%、例次感染率为17.29%;其中急性白血病患者医院感染率最高,为28.05%,其次为淋巴瘤患者26.88%,原发性血小板减少性紫癜患者医院感染率最低为2.20%;患者医院感染部位主要为呼吸系统,占51.61%,其次为血液、泌尿系统,分别占17.20%、11.83%;非条件多因素logistic回归分析,患者有院外感染、粒细胞缺乏、使用经外周静脉留置中心静脉导管(PICC)、化疗、有使用免疫抑制剂,患有急性白血病、多发性骨髓瘤、慢性白血病、骨髓增生异常综合征、恶性淋巴瘤等恶性血液病,以上因素存在是引起患者发生医院感染的独立危险因素(P<0.05)。结论血液科患者医院感染发生率较高,引起患者医院感染发生的危险因素较多,在患者入院后分析相关危险因素,进行针对性的预防,是降低医院感染发生的有效措施。OBJECTIVE To investigate the incidence of hospital infections and the high risk factors for hospital infections,in order to provide references for the prevention and control of hospital infections.METHODS Clinical data of 538 patients with hematological diseases during Jan.2012 to Jun.2013 were retrospectively analyzed.The incidence of hospital infections and its related factors were analyzed.The software SPSS16.0was used for statistical analysis and the unconditioned multivariate logistic regression analysis was used for multivariate analysis.RESULTS Among the 538 patients,hospital infection occurred in 76cases（the infection rate 14.13%）and 93case-times（the case-time infection rate 17.29%）.The hospital infection rate in patients with acute leukemia was the highest,up to 28.05%,followed by lymphoma patients（26.88%）,and was the lowest in patients with idiopathic thrombocytopenic purpura（2.20%）.The hospital infection site was mainly respiratory system（51.61%）,followed by blood（17.20%）and urinary system（11.83%）.The unconditioned multivariate logistic regression analysis showed exo-hospital infection,agranulocytosis,use of peripherally inserted central catheter,chemotherapy,use of immunosuppressants,suffering from acute leukemia,multiple myeloma,chronic leukemia,myelodysplastic syndrome,malignant lymphoma and other malignancies were independent risk factors for hospital infections（P〈0.05）.CONCLUSIONThe incidence of hospital infection in patients in the hematology department is high and there are many risk factors causing hospital infections.Analysis of related risk factors in patients after admission and targeted prevention and control are effective measures to reduce hospital infections.

关 键 词：血液科 医院感染 危险因素 

分 类 号：R181.32[医药卫生—流行病学]