放射性纤维化发病机制的研究现状与进展  

Recent advances in mechanisms of radiation-induced fibrosis

作　　者：刘琦 孙勇 邢星[1,2,3] 刘勇[1,2,3] 

机构地区：[1]复旦大学附属肿瘤医院肿瘤研究所 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]复旦大学附属肿瘤医院放疗科复旦大学上海医学院肿瘤学系,上海200032

出　　处：《辐射研究与辐射工艺学报》2015年第1期1-5,共5页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(81202148);教育部留学回国人员科研启动基金(N130204);2013年上海市浦江人才计划(13PJ1401600)资助

摘　　要：放射治疗是实体肿瘤治疗的有效手段之一,其原理是通过射线造成肿瘤细胞DNA损伤而达到治疗目的。然而射线本身不具有靶向性,对肿瘤细胞进行杀伤的同时亦会对受照区域内的正常组织造成不同程度的损伤。早期损伤多表现为急性炎症反应,晚期损伤以纤维化为主要病理改变,常导致受照器官结构和功能的改变,严重影响患者的生存质量。研究表明,放射性纤维化的形成涉及多种细胞因子,多个反应及组织微环境的变化等过程。本文将对放射性纤维化的发病机制的研究现状与进展进行综述。Radiation therapy is an effective treatment for solid tumors. Its effectiveness results from DNA damage of tumor cells induced by ionizing radiation （IR）. However, IR can also destroy normal tissues surrounding tumors in treatment of cancer. Early damages are featured with acute inflammatory response. Late damages are characterized by fibrosis, which would affect the structure and function of the targeting organs, even threaten the quality of patients＇ life. Previous studies suggested that radiation fibrosis process involves multiple cytokines, multiplex reactions and changes in the microenvironment. Here we review the current progress of molecular mechanisms on radiation-induced fibrosis.

关 键 词：放射 正常组织 晚期损伤 纤维化 

分 类 号：R730.55[医药卫生—肿瘤] TL71[医药卫生—临床医学]