621例乳腺浸润性导管癌患者分子分型与临床病理学特征的关系  

Correlations between molecular subtypes and clinical pathological features in 621 breast invasive ductal carcinoma patients

作　　者：杨利利[1] 艾秀清[1] 贺春钰[1] 朱相露[1] 木妮热·木沙江[1] 

机构地区：[1]新疆医科大学附属肿瘤医院乳腺放疗科,乌鲁木齐830011

出　　处：《实用肿瘤学杂志》2015年第1期34-38,共5页Practical Oncology Journal

基　　金：新疆医科大学科研创新基金（XJC201380）

摘　　要：目的 探讨新疆地区乳腺浸润性导管癌不同分子亚型的分布,并研究分子亚型与各临床病理学特征的关系。方法 收集2013年1月—2014年1月明确诊断为乳腺浸润性导管癌病例621例,根据雌激素受体（ER）、孕激素受体（PR）、表皮生长因子受体-2（HER-2）和Ki-67的表达情况,把所有病例划分为Luminal A型、Luminal B型、HER-2过表达型及Basal-like型,然后结合临床病理特征进行比较统计。结果 621例中Luminal B型占53.1%,Luminal A型、HER-2过表达型和Basal-like型分别占14.5%、15.9%、16.4%。各分子亚型与肿瘤大小、病理组织学分级、肿瘤病理分期、ER状态、PR状态、HER-2状态均有关（P＜0.05）,与年龄、淋巴结状态无关（P＞0.05）。结论 浸润性导管癌患者各分子亚型与其临床病理学特征有密切关系,分子分型有利于指导临床个体化治疗方案的制定。Objective To investigate the distribution of breast invasive ductal carcinoma with different molecular subtypes,and to study the relationship between molecular subtypes and clinical pathological features in Xinjiang area.Methods A total of 621 patients with IDC from January 2013 to January 2014 was classified into Luminal A type,Luminal B type,HER-2 overexpression type and Basal-like type,different molecular subtypes according to the estrogen receptor（ER）,progesterone receptor（PR）,epidermal growth factor receptor-2（HER-2）and Ki-67,and compared the statistics combining with the clinical pathological characteristics of IDC.Results The result showed that Luminal B type accounted for 53.1%,Luminal A type,HER-2 overexpression type and Basal-like type accounted for 14.5%,15.9%,16.4%,respectively.There were significant differences between the molecular subtypes and tumor size,histological grade,tumor pathological stage,the expression of ER,PR and HER-2（P＜0.05 for all）.There were no correlations between the molecular subtypes and age,as well as lymph node metastasis（P＞0.05）.Conclusion There is a close relationship between invasive ductal carcinoma of different molecular subtypes and clinical pathological characteristics.The molecular subtypes are beneficial to treatment guidelines for clinical individual.

关 键 词：乳腺浸润性导管癌 分子分型 临床病理学特征 

分 类 号：R737.9[医药卫生—肿瘤]