TRAIL及其相关凋亡调节机制在胆管癌中的研究进展  

Research progress on TRAIL and its related apoptosis regulating mechanism in cholangiocarcinoma

作　　者：赵云[1] 温锋[1] 赵相轩[1] 郭启勇[1] 

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110004

出　　处：《实用肿瘤学杂志》2015年第1期49-52,共4页Practical Oncology Journal

基　　金：国家自然科学基金面上项目（31371425）;辽宁省自然科学基金（2013023056）;辽宁省教育厅省财政厅科学研究项目（L2012289）

摘　　要：胆管癌（Cholangiocarcinoma,CCA）是常见的肝胆系统肿瘤。由于其对常规放化疗均不敏感,目前的治疗手段主要依赖于早期诊断行外科手术治疗。肿瘤坏死因子相关凋亡诱导配体（Tumor necrosis factor related apoptosis inducing ligand,TRAIL）通过与受体结合诱导细胞凋亡,在控制细胞增殖的过程中起着关键作用。尽管其可以选择性杀伤肿瘤细胞的特性使之成为癌症临床治疗的新方向,但是胆管癌细胞对TRAIL诱导凋亡耐受的情况制约着其应用范围。现今的研究发现多种信号通路能够调节胆管癌细胞对TRAIL诱导凋亡的敏感性。在这篇综述里,我们总结了TRAIL及其受体在胆管癌中的表达及作用,归纳了多种信号通路对恢复胆管癌细胞TRAIL诱导凋亡敏感性的机制。Cholangiocarcinoma （CCA） is a common cancer in hepatobiliary system.Because CCA is in sensitive to conventional chemotherapy and radiotherapy,the current treatment is mainly depending on the surgical operation when diagnosed early.Tumor necrosis factor related apoptosis inducing ligand （TRAIL） plays a key role in the process of controlling cell proliferation by binding with its receptor and therefore mediated cell apoptosis.Although the characteristic of selectively killing tumor cells by TRAIL makes it become the new direction of clinical treatment of cancer,the condition that CCA cells are resistant to TRAIL mediated apoptosis restricts its scope of application.Nowadays many studies demonstrate that multiple signaling pathways can regulate the sensitive of CCA cells to TRAIL mediated apoptosis.In this review,we summarize the expression and effects of TRAIL and its receptor in CCA,and conclude the mechanism of multiple pathways restoring the sensitivity of CCA cells to TRAIL mediated apoptosis.

关 键 词：胆管癌 肿瘤坏死因子相关凋亡诱导配体 细胞凋亡 

分 类 号：R735.8[医药卫生—肿瘤]