上海市浦东新区2002-2010年女性原发性乳腺癌流行状况及生存分析  

Prevalence and survival condition of primary breast cancer among female residents in Pudong New District,Shanghai City in 2002-2010

作　　者：闫蓓[1] 杨黎明[1] 杨琛[1] 吴铮[1] 李小攀[1] 高玉堂[2] 孙乔[1] 

机构地区：[1]上海市浦东新区疾病预防控制中心肿瘤伤害防治与生命统计科,上海200136 [2]上海交通大学肿瘤研究所

出　　处：《实用预防医学》2015年第2期165-168,共4页Practical Preventive Medicine

基　　金：上海市浦东新区卫生系统优秀青年医学人才培养项目(PWRq2012-24)

摘　　要：目的分析上海市浦东新区女性原发性乳腺癌发病、死亡及生存情况。方法利用2002-2010年浦东新区女性居民原发性乳腺癌的登记资料,分年龄组计算发病率、死亡率,用世界标准人口计算标化率,采用对数直线回归法估算发病率及死亡率的年度变化百分比（annual percent change,APC）,应用Life-Tables计算患者1~5年生存率,用KaplanMeier法分析不同TNM分期和是否知晓病情的乳腺癌患者的生存情况。结果 2002-2010年上海市浦东新区女性原发性乳腺癌新发患者5 990例,中位发病年龄53.92岁,粗发病率为51.69/10万,标化发病率为30.49/10万;因乳腺癌死亡病例1 686例,粗死亡率为14.55/10万,标化死亡率为8.13/10万。乳腺癌年龄别发病率高峰出现在45~49岁,高年龄段（〉60岁）发病率呈逐渐下降型。乳腺癌患者1~5年生存率分别为95.63%、91.61%、87.77%、84.32%和81.85%,不同TNM期别患者生存时间差异有统计学意义,早期患者（0~Ⅰ期）1~5年生存率高于中晚期患者（u（0~Ⅰ）期、Ⅱ期=25.63,u（0~Ⅰ）期、Ⅲ期=213.18,u（0~Ⅰ）期、Ⅳ期=697.57,P均〈0.001）。对较早期患者进行疾病告知有助于提高其生存率（u（0~Ⅰ）期=19.65,uⅡ期=7.67,P〈0.01）。结论乳腺癌是威胁浦东新区女性健康的重要恶性肿瘤,其发病高峰出现在45~49岁,肿瘤早发现及对于早期患者进行疾病的告知可改善其预后。Objective To analyze the incidence,mortality and survival rates of primary breast cancer among female residents in Pudong New District,Shanghai City from 2002 to 2010. Methods We collected the registered data about female residents with primary breast cancer in Pudong New District,Shanghai City during the period 2002- 2010,and then calculated the incidence and mortality rates of primary breast cancer based on different age groups. The standardized incidence and mortality rates of primary breast cancer were calculated by world standard population. The log linear regression method was used to calculate the annual percent changes（ APCs） of the incidence and mortality rates,and the Life- Tables was employed to calculate the 1-,2-,3-,4- and 5- year survival rates of patients with primary breast cancer. The survival rates of primary breast cancer patients with different TNM stages and different awareness about the condition of the illness were analyzed by Kaplan- Meier method. Results There were 5,990 new cases of primary breast cancer occurring during 2002- 2010,with a median age of 53. 92 years. The crude incidence rate was 51. 69 /100,000,and the standardized incidence rate was 30. 49 /100,000. There were 1,686 breast cancer death cases in total. The crude mortality rate was 14. 55 /100,000,and the standardized mortality rate was 8. 13 /100,000. The age- specific incidence curve showed a double- peak before and after menopause. The peak of the incidence rates appeared at the age of 45- 49 years,but the incidence rate of old- age group（〉60 years） gradually declined. The 1-,2-,3-,4- and 5- year survival rates of primary breast cancer patients were 95. 63%,91. 61%,87. 77%,84. 32% and 81. 85%,respectively.There were statistically significant differences in the survival rates of different TNM stages,and the 1- to 5- year survival rates of the early stage（ TNM- 0- I） were both higher than those of the median stage（ TNM- Ⅱ） and the advanced stage（ TNM- Ⅲand TNM- IV）,（ u0- I and Ⅱ= 25. 63,u0- I

关 键 词：乳腺癌 发病率 死亡率 生存率 

分 类 号：R737.9[医药卫生—肿瘤]