急性脑梗死患者氧化低密度脂蛋白与颈动脉内膜中层厚度的关系探讨  

The relationship between concentration of oxidized low density lipoprotein and carotid intima-media thickness in patients with acute cerebral infarction

作　　者：吴晓虹[1] 沈雄文[2] 赵园园[3] 叶小燕[1] 陈渠通 

机构地区：[1]南京军区杭州疗养院检验科,浙江杭州310007 [2]中国人民解放军第一一七医院检验科,浙江杭州310013 [3]中国人民解放军第一一七医院老年医学科,浙江杭州310013

出　　处：《国际检验医学杂志》2015年第3期301-302,305,共3页International Journal of Laboratory Medicine

摘　　要：目的研究急性脑梗死(ACI)患者氧化低密度脂蛋白(Ox-LDL)与颈动脉内膜中层厚度(IMT)之间的关系。方法采用酶联免疫吸附测定(ELISA)检测44例ACI患者(ACI组)和30例健康者(对照组)血清Ox-LDL水平,并对ACI患者进行颈动脉超声检查,检测颈动脉IMT,分析ACI患者Ox-LDL水平与颈动脉IMT的关系。结果 ACI患者Ox-LDL水平明显高于健康者,差异有统计学意义(P<0.01);颈动脉IMT≥1.0mm的ACI患者Ox-LDL水平高于颈动脉IMT<1.0mm者(P<0.05);ACI患者Ox-LDL水平与颈动脉IMT呈正相关(r=0.493,P<0.05)。结论 ACI患者的血清Ox-LDL水平升高,与颈动脉粥样硬化密切相关。Objective To study the relationship between the concentration of oxidized low density lipoprotein（Ox-LDL）and carotid intima-media thickness（IMT）in acute cerebral infarction（ACI group）.Methods 44 ACI patients（ACI group）and 30 healthy individuals（control group）were enrolled in the study,whose serum concentrations of Ox-LDL were determined by using enzymelinked immunosorbent assay（ELISA）,and carotid IMT of ACI patients were measured by using ultrasound,then the relationship between Ox-LDL and carotid IMT of ACI patients was analysed.Results The serum concentration of Ox-LDL in ACI group was significantly higher than that in control group（P〈0.01）.In ACI group,the serum concentration of Ox-LDL was positively correlated with carotid IMT（r=0.493,P〈0.05）.In ACI group,the serum Ox-LDL concentrations of patients whose IMT≥1.0were higher than patients whose IMT〈1.0mm（P〈0.05）.Ox-LDL concentrations of ACI patients were positively correlated with the carotid IMT（r=0.493,P〈0.05）.Conclusion The serum concentration of Ox-LDL increased significantly in ACI patients,and was closely related to carotid atherosclerosis.

关 键 词：急性脑梗死 氧化低密度脂蛋白 颈动脉内膜中层厚度 

分 类 号：R743.33[医药卫生—神经病学与精神病学]