β-catenin及c-Myc蛋白表达与口腔鳞状细胞癌相关性研究  

The expression of β-catenin and c-Myc in oral squamous cell carcinoma

作　　者：梁亚男[1] 刘宇[1] 牛星鉴 孙澄宇[1] 佟丹丹[1] 

机构地区：[1]哈尔滨医科大学基础医学院病理学教研室,150081

出　　处：《国际遗传学杂志》2015年第1期9-13,共5页International Journal of Genetics

基　　金：黑龙江省自然科学基金（ZD201316）

摘　　要：目的探讨βcatenin和c-Myc在原发性口腔鳞癌（OSCC）中的表达及意义。方法用免疫组化法检测口腔鳞癌及癌旁正常组织中β—catenin和c-Myc的表达。结果β—catenin在口腔鳞癌、相应癌旁正常组织中异常表达率分别为56．92％、15．38％，两组之间差异具有统计学意义（P=0．006），β-catenin异常表达增多与肿瘤大小（P=0．003）、局部的淋巴结转移密切相关（P=0．017）。在口腔鳞癌、相应癌旁正常组织中c-Myc的阳性表达率为64．62％，7．69％，两组之间差异具有统计学意义（P=0）。β—catenin在胞质的表达与C—Myc的表达呈正相关（rs=0．237，P=0．049）。结论c—Myc在口腔鳞癌中过表达，作为原癌基因促进肿瘤发生；β-catenin胞浆异常表达可能与口腔鳞癌的侵袭转移有关。Objective The purpose of this study was to investigate the expression of β-catenin and c-Myc in oral squamous cell carcinomas （ OSCC ）. Methods The expression of β-Catenin and C - myc was analyzed in 65 OSCC cases and 13 normal oral tissues by immunohistochemistry. Results The abnormal expression rate of β-Catenin was 56.92% in OSCC tissues, which was significantly higher than that in normal tissues （15.38% , P = 0. 006）. The expression of β-catenin was closely related with tumor size and lymph node metastasis （P = 0. 003, P = 0. 017, respectively）. The expression rate of c-Mye was 64.62% in OSCC tissues, which was significantly higher than that in normal tissues （7.69% , P = 0 ） . Furthermore, we found that the expression of β-Catenin in cytoplasm was positively correlated with the expression of c-Myc protein in OSCC （ rs = 0. 237, P = 0. 049 ）. Conclusion Overexpression of c- Myc may play an important role in the development and progression of OSCC, and the expression of β-catenin in cytoplasm was associated with the metastasis of OSCC.

关 键 词：口腔鳞癌 Β-CATENIN C-MYC 转移 

分 类 号：R739.85[医药卫生—肿瘤]