急性脑梗死血小板聚集及活化指标的变化及临床意义  

Changes and clinical significance of platelet aggregation and activation markers in patients with acute cerebral infarction

作　　者：但刚[1] 江忠勇[1] 刘媛[1] 胡莉娜[1] 熊杰[1] 

机构地区：[1]成都军区总医院临床实验医学研究与保障中心检验科,成都610083

出　　处：《西南国防医药》2015年第2期124-126,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：四川省卫计委科研课题(140007);国家高技术研究发展计划(863计划)(2011AA02A111)

摘　　要：目的观察急性脑梗死(acute cerebral infarction,ACI)患者血小板聚集性及血小板活化指标P选择素、膜GPⅡb/Ⅲa的变化,探讨活化血小板在ACI发病中的作用。方法选取75例急性脑梗死患者作为ACI组,选取78例健康体检者作为正常对照组。利用血小板聚集测试仪、流式细胞仪,检测两组对象血小板聚集率及血小板表面表达的P选择素、膜GPⅡb/Ⅲa等活化指标含量。结果与正常对照组比较,ACI患者组的血小板聚集率明显升高(P<0.05),血小板表面表达的P选择素、膜GPⅡb/Ⅲa明显升高(P<0.05)。结论 ACI患者血小板活化水平明显升高,聚集功能明显增强,患者处于高凝状态,是导致ACI发生的重要原因之一。Objective To observe the changes of platelet aggregation and platelet activation markers P selectin and membrane GPⅡb/Ⅲa in patients with acute cerebral infarction（ACI） and study the role of platelet activation in the pathogenesis of ACI. Methods Patients with ACI were selected to constitute an ACI group（ n = 75 ）and healthy subjects were selected to constitute a control group（ n = 78 ）. Aggregation tester and flow cytometry were used to check the platelet aggregation and contents of activation markers expressed on platelet surface,including P selectin and membrane GP II b/11I a. Results Compared with the control group, the platelet aggregation of the patients in the ACI group increased significantly （ P 〈 0.05 ）, and P selectin and membrane GPⅡb/Ⅲa expressed on platelet surface increased significantly（P 〈 0.05 ）. Conclusion It is one of the important reasons to cause the incidence of ACI that the level of platelet activation in patients with ACI becomes significantly higher, the aggregation function is enhanced obviously, or the patients are in hypereoagulable state.

关 键 词：脑梗死 血小板聚集 P选择素 GPⅡb/Ⅲa 

分 类 号：R743.32[医药卫生—神经病学与精神病学]