骨髓增殖性肿瘤患者JAK2V617F突变和脑血管事件的相关性研究  

Study on the correlation of JAK2V617F mutation and cerebrovascular events in patients with myeloproliferative neoplasms

作　　者：郭慧梅[1] 贺建辉[2] 李云鹏[3] 尚雪飞[3] 周云[3] 宗围 彭燕[3] 

机构地区：[1]河北大学附属医院血液内科,河北保定071000 [2]保定市第一中心医院神经外科,河北保定071000 [3]保定市第一医院,河北保定071000

出　　处：《医学研究与教育》2014年第6期28-30,共3页Medical Research and Education

摘　　要：目的研究骨髓增殖性肿瘤(MPN)患者JAK2V617F突变与脑血管事件的相关性。方法检测64例MPN患者JAK2V617F突变情况,回顾性分析64例MPN患者脑血管事件(脑梗死、短暂性脑缺血发作、脑出血、蛛网膜下腔出血)发生情况等资料,统计分析JAK2V617F突变阳性组与阴性组脑血管事件的发生率,并分析JAK2V617F突变阳性的不同病种间脑血管事件发生率。结果 64例MPN患者中47例(73.4%)存在JAK2V617F突变,38例有脑血管事件(59.4%),JAK2V617F突变阳性和阴性患者中脑血管事件发生率分别为68.1%和35.3%,2组间P=0.018。JAK2V617F突变阳性的PV和ET患者脑血管事件发生率差异无统计学意义。结论 JAK2V617F突变阳性较突变阴性的MPN患者脑血管事件发生的风险可能更高。Objective To investigate the relationship of JAK2V617F mutation and cerebrovascular events in patients with myeloproliferative neoplasms（MPN）.Methods The JAK2V617F mutation of 64 patients with MPN was detected. We performed a retrospective study on the incidence of cerebrovascular events（cerebral infarction, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage） in 64 patients with MPN. Statistical analysis was applied on the incidence rate of cerebrovascular events between JAK2V617F mutation positive group and negative group and between groups of different diseases with JAK2V617F mutation.Results Of 64 patients with MPN, JAK2V617F mutation was detected in 47 cases （73.4%）. There were a total of 38（59.4%） cerebrovascular events. The incidence rate of cerebrovascular events in JAK2V617F mutation positive and negative patients were 68.1% and 35.3% respectively, P=0.018. The incidence rate between PV and ET patients with JAK2V617F mutation were statistically non-signiifcant.Conclusion The risk of cerebrovascular events in MPN patients with JAK2V617F mutation may be higher.

关 键 词：骨髓增殖性肿瘤 JAK2V617F 出血 血栓 

分 类 号：R73[医药卫生—肿瘤]