胃腺癌CerbB-2蛋白表达及临床分析  

The Expression of Cerb B-2 protein in the Gastric Adenocarcinoma and Its Clinical Significance

作　　者：闵静[1] 戴一菲[2] 

机构地区：[1]湖北职业技术学院医学院,湖北孝感432000 [2]孝感市中心医院,湖北孝感432000

出　　处：《湖北职业技术学院学报》2014年第4期106-109,共4页Journal of Hubei Polytechnic Institute

基　　金：湖北职业技术学院院级课题"Cerb B-2在胃癌TNM分期及微转移鉴别中的应用研究"(项目编号:2013B07)的阶段性研究成果

摘　　要：目的:研究胃腺癌原癌基因Cerb B-2在肿瘤发生、发展过程中的作用并探讨其临床相关性。方法:应用免疫组织化学法(IHC)对435例胃腺癌组织标本、95例正常切缘粘膜组织标本中Cerb B-2基因的表达情况进行检测。结果:Cerb B-2基因在胃腺癌组织、正常切缘组织中的表达阳性率分别为30.8%、16.8%,差异有统计学意义(P<0.01);在胃腺癌组织中,Cerb B-2基因的表达与患者的年龄、性别、肿瘤大小、分化程度均无相关性(P>0.05),而与肿瘤的临床分期(TNM分期)相关,差异有统计学意义(P<0.01)。结论:Cerb B-2基因与胃腺癌有明显的关联,可作为判定胃癌中最多见的胃腺癌的生物学行为的重要参考指标,对临床治疗及预后判定都能起到一定作用。To investigate Cerb B- 2 protein in the gastric adenocarcinoma and clinical significance. Methods：By using the immunohistochemical method,435 cases of gastric adenocarcinoma tissue and 95 cases of the normal margin of mucosal tissue were detected the expression of Cerb B- 2. Results： The positive rate of Cerb B- 2 expression in gastric adenocarcinoma tissues,normal margin of mucosal tissues accounted for 30. 8% and 16. 8% respectively; There were significantly differences between them. In gastric cancer tissues,there was no correlation between Cerb B- 2 expression and the patients’ age gender,tumor size and tumor differentiation（ P 〉 0. 05）,while there existed significant difference in the tumor clinical stage（ P 〈 0. 01）. Conclusion： Cerb B- 2 is closely related to gastric adenocarcinoma,and it can be considered as important index for determining the biological behavior of gastric adenocarcinoma. It also can play a certain role in clinical treatment and prognosis judgment.

关 键 词：胃腺癌 CERBB-2 免疫组织化学 临床 

分 类 号：R735.2[医药卫生—肿瘤]