扶正健脾抗癌汤减轻乳腺癌患者化疗副作用临床疗效观察  

Observation of Fuzheng Kangai Decoction Improving Side Effect of Chemotherapy in Breast Tumor

作　　者：李天威[1] 赵云清[2] 徐宏[1] 李京宁[3] 

机构地区：[1]辽宁省肿瘤医院,辽宁沈阳110042 [2]辽宁中医药大学附属第四医院,辽宁沈阳110101 [3]解放军第二0二医院,辽宁沈阳110003

出　　处：《辽宁中医药大学学报》2015年第2期151-153,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察扶正健脾抗癌汤改善乳腺癌患者化疗副作用的临床疗效。方法:应用随机平行对照方法,将69例住院患者,随机分为两组。对照组35例患者应用CEF方案化疗,治疗组34例患者应用扶正健脾抗癌汤100 m L,日3次口服;化疗用法、用量与对照组相同,治疗21 d为1个疗程,共行4周期化疗。观察比较中医症状评分、临床疗效、消化道反应、骨髓抑制情况、细胞免疫功能相关指标。结果:第3、4周期,治疗组症状评分下降明显,而对照组则评分增高,两组与治疗前比较,差异均具有统计学意义(P<0.01),且两组组间比较差异显著(P<0.01);治疗后,治疗组改善率为74.3%;对照组改善率为58.8%。两组患者生活质量改善率比较有显著性差异(P<0.05);治疗后,治疗组白细胞及血小板计数较治疗前,均不同程度减少(P<0.05),但减少程度低于对照组(P<0.05),治疗组白细胞下降分级明显低于对照组(P<0.05),两组血小板下降分级无明显差异(P>0.05);治疗组消化道症状评分明显低于对照组(P<0.05)。治疗后,两组患者T淋巴细亚群(CD+3、CD+4)及免疫球蛋白Ig A、Ig M均下降,与治疗前比较差异有统计学意义(P<0.05),但治疗组下降程度均较对照组轻,差异具有统计学意义(P<0.05)。结论:扶正健脾抗癌汤可以改善患者化疗期间的副作用,减轻化疗毒副作用,缓解不适症状,提高患者生存质量,临床疗效显著。Objective：To observe Fuzheng Kangai decoction improve the clinical efficacy of breast cancer chemotherapy side effects. Method：Randomized parallel-group method,69 cases of hospitalized patients were randomly divided into two groups Chi. Application control group of 35 patients CEF chemotherapy,the treatment group 34 cases of spleen cancer patients righting soup 100 m L,three times a day orally;chemotherapy usage,the same amount with the control group,treatment 21 d for a course of treatment,a total of four cycles of chemotherapy lines. To compare the clinical symptoms score,clinical efficacy,gastrointestinal reactions,bone marrow suppression,the cellular immune function related indicators. Results：In the third and forth cycle,the treatment group symptom score decreased significantly,while the control group scores increased,and treatment of the first two groups,the difference was statistically significant（P〈0.01）,and the comparison between the two groups significant differences（P〈0.01）;after treatment,the treatment group improvement rate was 74.3%;improvement rate was 58.8% in the control group. Have more to improve the quality of life of patients in both groups was significant difference（P〈0.05）;after treatment group WBC and platelet counts before treatment,were reduced to varying degrees（P〈0.05）,but to reduce the degree lower than the control group（P〈0.05）,leukopenia grade treatment group was significantly lower than the control group（P〈0.05）,the two groups had no significant difference in platelet decline in grade（P〉0.05）;gastrointestinal symptom scores in treatment group was significantly lower than the control group（P〈0.05）. After treatment,patients were T lymphocyte subsets（CD^＋3 CD^＋4）and immunoglobulin Ig A,Ig M decreased,and was statistically significant（P〈0.05）difference before treatment,but the treatment group decreased mild degree than the control group,the difference was statistically significant（P〈0.05）. Conclusion：Righting s

关 键 词：乳腺癌 扶正健脾抗癌汤 化疗 副作用 

分 类 号：R737.9[医药卫生—肿瘤]