应用双通道客观视觉质量分析系统与光线追踪波阵面像差系统分析正常人眼调制传递函数  

Comparison of ocular modulation transfer function measurements by ray tracing wavefront technology and double-pass system

作　　者：乔利亚[1] 蔡啸谷[1] 万修华[1] 管征[1] 熊瑛[1] 林仲[1] 张烨[1] 谭家璿[1] 王宁利[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼科杂志》2015年第1期20-25,共6页Chinese Journal of Ophthalmology

摘　　要：目的 比较双通道客观视觉质量分析系统（OQASⅡ）与光线追踪波阵面像差系统（iTrace）测量正常人眼调制传递函数（MTF）的一致性,寻找更准确的客观视觉质量评价手段.方法 对比研究.连续收集前往设置在邯郸市永年县东杨庄中心卫生院的邯郸眼病研究检查现场健康受试者进行研究,对排除眼部疾病后的受试者进行散瞳前对比敏感度检查、散瞳后使用OQASⅡ与iTrace测量全眼MTF.比较两者在4.0和6.0 mm瞳孔直径下5、10、15、20、25、30周/度（c/d）空间频率下消除低阶像差影响后的MTF均值,对符合正态分布的两种仪器在不同空间频率的MTF测量值进行配对t检验.绘制Bland-Altman图进行一致性评价,并分别对两种仪器的MTF测量值与最佳矫正视力、不同空间频率下对比敏感度进行Spearman秩相关分析.结果 共有163例（251只眼）患者入选本研究,其中男性81例（139只眼）,女性82例（112只眼）,年龄30 ～ 60岁,平均（44.1±9.7）岁.在4.0 mm瞳孔直径下iTrace在5、10、15、20、25、30 c/d空间频率下的MTF均值分别为0.730±0.138、0.431 ±0.159、0.262±0.120、0.169 ±0.078、0.118 ±0.053、0.094±0.043,OQASⅡ分别为0.347±0.123、0.162 ±0.086、0.072 ±0.049、0.042±0.033、0.026±0.022、0.017 ±0.022,两种仪器的差异均有统计学意义（t=38.72,28.03,27.32,27.59,29.23,28.96;P ＜0.01）;在6.0 mm瞳孔直径下,两种仪器的差异也有统计学意义（t =4.60,3.19,9.34,13.41,16.96,20.24;P ＜0.01）.Bland-Altman一致性分析法提示两者一致性较差,但在6.0 mm瞳孔直径两者一致性有所提高.iTrace MTF测量值与最佳矫正视力呈负相关（r=-0.139～-0.165,P＜0.01）,部分空间频率MTF值与6 c/d空间频率对比敏感度Log值呈正相关（r=0.163 ～0.175）,P＜0.05）;OQASⅡMTF值与最佳矫正视力呈负相关（r=0.239 ～0.303,P＜0.01）,各空间频率MTF值与3、6、12、18 c/d空间频率对比敏感度Log值均呈正相关（r Objective To compare the agreement of the ocular modulation transfer function （MTF）measured by double-pass system and ray tracing wavefront aberrometry,and to analyze the correlations of two MTFs with the visual acuity and contrast sensitivity function results.Methods Comparative study.Subjects with no ocular diseases were consecutively enrolled in an epidemic study field located at the Dongyangzhuang Health Center,Yongnian County,Handan City,Hebei Province,China.After comprehensive ophthalmic examinations,the mean values of subtracted lower order aberration MTF at 5,10,15,20,25,and 30 cycle/degree（c/d） spatial frequencies were obtained with a double-pass system（optical quality analysis system Ⅱ,OQAS Ⅱ system）and a ray tracing wavefront aberrometer（iTrace visual function analyzer,iTrace system）in the 4.0 mm and 6.0 mm pupil after dilation,respectively.Paired-sample t test and Bland-Altman analysis were used to compare the difference and agreement of MTFs obtained with two instruments.Correlation analysis was preformed between two MTF measurement results and subjective visual quality including visual acuity and contrast sensitivity function.Results Two hundred and fifty-one healthy eyes of 163 subjects were enrolled,aged 30 to 60,mean （44.1 ±9.7） years,including 139 eyes of 81 males and 112 eyes of 82 females.The mean value of MTF at 5,10,15,20.25,30 c/d obtained by iTrace in 4.0 mm pupil were 0.730 ±0.138、0.431 ± 0.159、0.262 ±0.120、0.169 ±0.078、0.118 ±0.053、0.094 ±0.043.The value obtained by OQAS Ⅱ were 0.347 ± 0.123、0.162 ± 0.086、0.072 ± 0.049、0.042 ± 0.033、0.026 ± 0.022、0.017 ±0.022,The result of iTrace were all significant higher than OQAS in both 4mm（t =38.72,28.03,27.32,27.59,29.23,28.96,P〈0.01） and 6.0 mm（t =4.60,3.19,9.34,13.41,16.96,20.24,P 〈0.01）pupil diameter.The iTrace-OQAS Ⅱ MTF difference was smaller in the 6.0 mm pupil.Bland-Altman analysis indicated that the agreement of two instruments was poor,while the limits of agreement i

关 键 词：角膜波前像差 像差测量 诊断技术 眼科 对比敏感度 视敏度 

分 类 号：R770.4[医药卫生—眼科]