微小RNAs与新生血管形成  

MicroRNAs and angiogenesis

作　　者：杨子岩[1] 晏贤春[2] 赵星成[2] 张萍[2] 韩骅[2] 

机构地区：[1]第四军医大学学员旅,陕西西安710032 [2]第四军医大学医学遗传学与发育生物学教研室,陕西西安710032

出　　处：《心脏杂志》2015年第1期102-105,109,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(31370769)

摘　　要：新生血管形成是一种复杂的动态过程,其是在原有血管基础上通过促血管生成途径以及抗血管生成途径之间严密的协同作用而形成的。促血管生成途径与抗血管生成途径之间的平衡一旦被打破,则可导致病理性的新生血管形成,参与到肿瘤、炎症、心血管疾病等多种疾病的发生发展过程中。微小RNAs(miRNAs)可在mRNA和蛋白质水平调节基因表达,是细胞生命活动中重要的小分子调节物质。不同的miRNAs通过对特定靶基因的调节,在新生血管形成中发挥着重要作用。本文将就调控新生血管形成的重要miRNAs及其潜在的临床应用价值做一综述。Angiogenesis is a complex process a collaboration of pro- and anti-angiogenic during signaling which new vessels shape from pre-existing vasculature by pathways. However, in pathological situations, the same angiogenic signaling pathways are dysregulated and exploited, typically resulting in cancer, inflammation and other cardiovascular diseases. MicroRNAs have emerged as a novel class of endogenous, small and non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of mRNAs and proteins. Recent studies have illustrated that microRNAs play incomparable roles in angiogenesis via regulating vascular cell differentiation, migration, proliferation and apoptosis through their target genes. This review summarizes the latest insights in the identification of vascular-specific microRNAs and discusses their potential clinical applications in vascular diseases.

关 键 词：新生血管生成 MICRORNA 调节网络 靶基因 

分 类 号：R394.1[医药卫生—医学遗传学] R331.32[医药卫生—基础医学]