琥珀酸脱氢酶B在局部复发鼻咽癌组织中的低表达及其与预后的关系  

Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis

作　　者：林森[1] 戴志坚[1] 陈崇喜[1] 潘升华[2] 廖志苏[3] 

机构地区：[1]温州医科大学附属第三医院耳鼻咽喉科,浙江省瑞安市325200 [2]温州医科大学附属第三医院病理科,浙江省瑞安市325200 [3]温州医科大学附属第一医院耳鼻咽喉科

出　　处：《中华耳鼻咽喉头颈外科杂志》2015年第1期38-42,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：温州市科技计划项目(Y20120022);瑞安市科技计划项目(201203081)

摘　　要：目的 研究琥珀酸脱氢酶B（succinate dehydrogenase subunit B,SDHB）在局部复发鼻咽癌组织中的表达与患者临床病理因素的关系及其与预后的关系.方法 采用免疫组化法检测51例局部复发鼻咽癌患者肿瘤组织和42例初发鼻咽癌患者肿瘤组织中SDHB的表达情况,运用x2检验分析其与临床病理因素的关系、Kaplan-Meier法进行生存分析、Cox比例风险模型进行复发多因素分析.结果 初发鼻咽癌组织中SDHB低表达率为57.1％（24/42）,局部复发鼻咽癌组织中SDHB低表达率为76.5％（39/51）,差异有统计学意义（x2=3.937,P＜0.05）.SDHB低表达与局部复发鼻咽癌患者的T分期、临床分期、脑神经侵犯等有关（P值均＜ 0.05）,Kaplan-Meier生存分析显示,SDHB表达降低与患者低生存率有关（x2=4.154,P＜0.05）,多因素Cox回归分析显示,SDHB低表达、远处转移、脑神经侵犯是影响鼻咽癌复发的独立危险因素（P值均＜ 0.05）.结论 SDHB表达降低对鼻咽癌的局部复发、预后不良可能起着重要作用,SDHB低表达可作为判断鼻咽癌复发及预后一种新的分子标志物.Objective To study the expression of succinate dehydrogenase subunit B（SDHB） in the tissues of locally recurrent nasopharyngeal carcinoma （rNPC） and the correlation with the clinicopathological factors and prognosis of rNPC.Methods Immunohistochemistry was used to detect the expression of SDHB in the tissues of primary and locally recurrent nasopharyngeal carcinoma.The relationship between SDHB expression and clinicopathological features was analyzed using the Chi-square test,and Kaplan-Meier method and Log-rank test were used for survival analysis.The independent prognostic factors of rNPC were analyzed by Cox regression model.Results Low SDHB expression was showed in 76.5％ （39/51） of the patients with rNPC,significantly higher than 57.1％ （24/42） of primary nasopharyngeal carcinoma （x2 =4.098,P ＜ 0.05）.Low expression of SDHB strongly was correlated with T classification,clinical stage and cranial nerve palsy.Patients with low SDHB expression had a shorter survival time and a lower 3 or 5 year survival rate compared to the patients with high SDHB expression.Multivariate analysis showed that low SDHB expression was an independent predictor for overall survival of patients with rNPC （P ＜ 0.05）.Conclusion The low SDHB expression is an independent indicator for poor prognosis of rNPC and may play an important role in the recurrence of rNPC.

关 键 词：鼻咽肿瘤 琥珀酸脱氢酶 预后 

分 类 号：R739.63[医药卫生—肿瘤]