3D打印钛合金个性化骨盆假体生物力学的初步有限元分析  

Biomechanical properties of a titanium alloy pelvic prosthesis individually manufactured by 3D printing： a finite element analysis

作　　者：叶堃[1] 王金武[2] 胡志刚[1] 王成焘[3] 干耀凯 韦建和[3] 江川[2] 邓源[3] 李雨[1] 徐嘉炜[2] 郝永强[2] 严孟宁[2] 戴魁戎[2] 

机构地区：[1]河南科技大学,471003 [2]上海市骨科内植物重点实验室、上海交通大学医学院附属第九人民医院骨科 [3]上海交通大学生物医学工程学院

出　　处：《中华创伤骨科杂志》2015年第1期18-22,共5页Chinese Journal of Orthopaedic Trauma

基　　金：国家重大科学研究计划（2011CB013300,2012CB933604）;国家自然科学基金（81171707）,上海市卫生系统重要疾病联合攻关项目（2013ZYJB0501）,上海教委重点学科建设基金（J50206）

摘　　要：目的通过有限元分析的方法评价3D打印钛合金骨盆假体的生物力学性能。方法选取1例男性右侧髂骨巨大软骨肉瘤患者，拟行半骨盆切除人工半骨盆置换术。术前行CT和MRI检查，利用三维图像融合技术判断髂骨周围肿瘤侵袭范围，确定外科边缘及截骨平面，根据截骨后骨盆缺损范围利用计算机辅助设计（CAD）建立患者骨盆有限元模型，经过有限元分析后利用3D打印技术定制个性化钛合金骨盆假体。在Abaqus软件中对已建立的3D打印骨盆假体模型进行有限元分析，测量骨盆假体的von Mises应力、相对位移和整个有限元模型的应力集中点。结果3D打印钛合金骨盆假体的最大von Mises应力为25．29MPa，远小于钛合金的屈服强度（950MPa）。应力集中区域为假体与骶骨连接钉孔附近。患者术后3个月逐渐弃拐行走，术后半年假体情况稳定，患者活动正常。结论根据有限元模型计算结果，3D打印钛合金骨盆假体可满足生物力学要求，计算结果与患者术后随访结果一致，该方法可为3D打印骨科内置物临床应用提供生物力学依据。Objective To evaluate the biomeehanieal properties of a titanium alloy pelvic prosthesis individually manufactured by 3D printing through finite element analysis. Methods A male patient with a huge chondrosarcoma at the right ilium was recruited for the present study who had been arranged for hemipelvectomy and artificial hemi-pelvic replacement. After the patient underwent CT and MRI examinations before operation, scope of tumor invasion around the ilium, surgical margins and plane for osteotomy were determined using the 3D image fusion technique. A finite element model of the pelvis of the patient was established on the basis of the defective area after pelvic osteotomy using computer aided design （CAD）. After the finite element analysis, a customized titanium alloy pelvic prosthesis was manufactured using 3D printing technology. The software Abaqus was used to conduct finite element analysis of the model of the pelvic prosthesis manufactured by 3D printing. The yon Mises stress, relative displacement and stress concentration point in the finite element model of the pelvis were measured and analyzed. Results The maximum yon Mises stress in the titanium alloy pelvic prosthesis manufactured by 3D printing was 25.29 MPa, far smaller than the yield strength of titanium alloy （950 MPa） . The stress concentration area was near the nail holes where the prosthesis and the sacrum were connected. The patient was able to walk without crutches 3 months post-surgery. After half a year, the implant was stable and the patient could perform normal activities. Conclusions The titanium alloy pelvic prosthesis individually manufactured by 3D printing based on the results of finite element analysis met the biomechanical requirements of a pelvis. The calculation results of finite element analysis were consistent with the postoperative follow-up outcomes of the patient. This method can provide biomechanical evidence for clinical application of 3D printing implants in orthopedics.

关 键 词：骨盆 假体与置入物 有限元分析 3D打印技术 

分 类 号：R738.1[医药卫生—肿瘤] TP391.73[医药卫生—临床医学]