新疆汉族鼻咽癌患者HLA-A* 02基因表达及多态性分析  

Analysis of gene expression and polymorphism of allele HLA-A* 02 of Han patients with nasopharyngeal carcinoma in Xinjiang

作　　者：刘凯[1] 谭遥[1] 李亚伟[1] 王多明[1] 吾甫尔江.艾克木 王若峥[1] 

机构地区：[1]新疆医科大学附属肿瘤医院头颈放疗科,乌鲁木齐830011

出　　处：《上海交通大学学报（医学版）》2015年第1期59-62,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81160327);新疆维吾尔自治区国际合作基金(20126024;201141138)~~

摘　　要：目的探讨新疆汉族鼻咽癌患者HLA-A*02等位基因及其亚型的表达与鼻咽癌发病的关系。方法采用聚合酶链反应/序列特异性引物(PCR-SSP)的方法对63例新疆汉族鼻咽癌患者和51名汉族健康志愿者HLA-A等位基因进行分析,比较2组HLA-A*02等位基因及其亚型的差异。结果鼻咽癌患者共检出HLAA*02等位基因51个(频率39.7%),健康人群检出HLA-A*02等位基因17个(频率16.7%),2组比较差异有统计学意义(P=0.002);鼻咽癌患者共检出7个HLA-A*02等位基因亚型,健康人群检出4个等位基因亚型,2组比较差异无统计学意义(P>0.05),各亚型构成比比较差异无统计学意义(P>0.05)。结论HLA-A*02等位基因与新疆汉族鼻咽癌患者的发病有关,新疆鼻咽癌患者HLA-A*02等位基因亚型分布存在自身特点。Objective To explore the relationship between the polymorphism of allele HLA-A ＊ 02 and the incidence of nasopharyngeal carcinoma （NPC） of Han patients in Xinjiang. Methods Polymerase chain reaction/sequence-specific primers （PCR-SSP） method was adopted to analyze HLA-A alleles of 63 Han patients with NPC in Xinjiang and 51 health Han volunteers. The differences of allele HLA-A ＊ 02 and its subtypes of two groups were compared. Results The frequency of allele HLA-A ＊ 02 in NPC patients was 39.70/0 （51/126） and the frequency of allele HLA-A ＊ 02 in healthy people was 16.70/0 （17/102）. The difference was statistically significant （P=0. 002）. Seven subtypes of allele HLA-A ＊ 02 were detected in NPC patients and 4 subtypes of allele HLA-A ＊ 02 were detected in healthy people. The difference was not statistically significant （P〉0.05） . The differences of constituent ratios of subtypes were not statistically significant （ P 〉 0.05）. Conclusion The allele HLA-A ＊ 02 is relevant to the incidence of NPC of Han patients in Xinjiang. The distribution of subtypes of allele HLA-A ＊ 02 of NPC patients in Xinjiang have their own features.

关 键 词：头颈部肿瘤 鼻咽癌 HLA 多态性 T细胞免疫 

分 类 号：R739.63[医药卫生—肿瘤]