组织工程角膜内皮细胞移植的研究与进展  

Research advances on tissue-engineered corneal endothelial cells transplantation

作　　者：赵思婕[1] 刘焰[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,中国上海市200080

出　　处：《国际眼科杂志》2015年第2期219-222,共4页International Eye Science

基　　金：国家自然科学基金面上项目(No.81371068)~~

摘　　要：由于角膜供体材料严重短缺以及供体年龄限制,穿透性角膜移植术的临床广泛开展受到严重制约,应用组织工程体外培养高密度、具备常规六角形态和健康内皮功能的角膜内皮细胞是当前研究的热点。本文就角膜内皮种子细胞的来源、载体的选择及角膜内皮细胞移植方法、免疫机制等方面研究的最新进展进行综述,总结目前研究面临的问题并展望其前景。Due to the serious shortage of donor cornea materials and the donor limit, clinical popularization of penetrating keratoplasty is severely restricted. lt is a hot spot of current research that applying tissue engineering in vitro to culture corneal endothelial cells （ CEC ） with high density, regular hexagonal shape and healthy endothelial function. ln this article, we reviewed the latest progress in the study of source of CEC seeder cells, selection of cultivating carries, type of CEC transplantation and immune mechanism that summarized the current research problems and made a prospect to the future.

关 键 词：角膜内皮细胞 种子细胞 载体 移植 组织工程 

分 类 号：R779.65[医药卫生—眼科]