CUEDC2在肝细胞癌组织中的表达及其临床预后的意义  

Prognostic significance of CUEDC2 expression in hepatocellular carcinoma

作　　者：王伯庆[1] 薛峰[1] 丁伟[1] 唐建军[2] 康铁邦[2] 毛拉艾沙·买买提[1] 李海军[1] 唐津天[1] 董晓刚[1] 尹继炜[1] 依马木买买提江·阿布拉[1] 易超[1] 徐林[1] 佟庆[1] 张国庆[1] 

机构地区：[1]新疆医科大学附属肿瘤医院肝胆胰外科,新疆乌鲁木齐830011 [2]华南肿瘤学国家重点实验室,中山大学肿瘤防治中心,广东广州510060

出　　处：《中国病理生理杂志》2015年第1期124-129,共6页Chinese Journal of Pathophysiology

基　　金：新疆医科大学校内重点特色学科项目(No.XYDXK50780306)

摘　　要：目的:检测含CUE结构域蛋白2(CUEDC2)在肝细胞癌组织中的表达,探讨其与临床预后的关系。方法:选取具有完整临床及预后资料的186例手术切除肝细胞癌组织的石蜡组织标本,采用免疫组化技术检测CUEDC2的表达,并结合肝癌临床病理因素及预后进行分析。结果:CUEDC2在85.5%(159/186)的肝癌组织中有表达,其中低表达为52.2%(97/186),高表达为47.8%(89/186);CUEDC2的表达状态与血清甲胎蛋白(AFP)水平、肿瘤大小、肿瘤数目、肝癌分化程度和TNM分期有关(P<0.05)。Kaplan-Meier生存分析显示CUEDC2高表达的患者术后总生存及无复发生存期较低表达者显著缩短;多因素Cox回归分析显示CUEDC2的表达状态、血清AFP和肿瘤数目是影响肝癌患者术后无复发生存(RFS)及总生存期(OS)的独立危险因素。结论:CUEDC2在多数肝癌组织中有表达,与肿瘤的生长、分化及预后有关;CUEDC2可以作为一个有价值的肝癌预后预测的新指标。AIM：To investigate the expression of CUE domain-containing 2 （CUEDC2） in hepatocellular car-cinoma （ HCC） and to analyze its clinical prognostic significance .METHODS：Total 186 formalin-fixed paraffin-embed-ded tissues obtained from surgical HCC with detailed clinicopathological and follow -up data were used .The expression of CUEDC2 was detected by immunohistochemistry .The relationships between the expression of CUEDC 2 and clinicopatholog-ical characteristics and prognosis were analyzed .RESULTS： The positive rate of CUEDC 2 in HCC was 85.5% （ 159/186）, among which, the low expression was 52.2%（97/186） and the high expression was 47.8%（89/186）.CUEDC2 expression was correlated with serum alpha-fetal protein （AFP） level, tumor size, tumor number, tumor differentiation and TNM stage （P〈0.05）.Kaplan-Meier survival curves showed that the patients with high expression of CUEDC 2 were asso-ciated with significantly shorter overall survival and recurrence-free survival than those with low CUEDC 2 expression （ P〈0.05）.Multivariate Cox regression analysis revealed 3 independent prognostic factors including CUEDC 2 expression, ser-um AFP and tumor number .CONCLUSION：CUEDC2 was expressed in most HCC tissues , which was relevant to tumor growth, tumor differentiation and prognosis .CUEDC2 could be a novel valuable molecular marker to predict the HCC prog-nosis.

关 键 词：肝肿瘤 肝切除术 CUEDC2蛋白 预后 

分 类 号：R735.7[医药卫生—肿瘤]