TK1与CA153及CEA联合检测对乳癌诊断临床价值  

CLINICAL VALUE OF COMBINED DETECTION OF TK1,CA153 AND CEA IN THE DIAGNOSIS OF BREAST CANCER

作　　者：李萍[1] 刘艳凤 张少强[1] 陈增生[3] 

机构地区：[1]青岛大学附属医院输血科,山东青岛266003 [2]青岛市北区人民医院检验科 [3]青岛市市立医院检验科

出　　处：《齐鲁医学杂志》2015年第1期10-11,14,共3页Medical Journal of Qilu

摘　　要：目的 探讨血清胸苷激酶1（TK1）、糖类抗原153（CA153）与癌胚抗原（CEA）联合检测诊断乳癌的临床价值。方法 用化学发光法检测216例乳房良性疾病病人、105例乳癌病人、100例健康体检者血清中TK1、CA153、CEA的含量。结果 乳癌病人血清TK1、CA153、CEA水平均显著高于乳房良性疾病病人和健康体检者（F=3.38-3.62,P〈0.05）;乳癌病人TK1、CA153、CEA联合检测阳性率高于三项指标单独检测阳性率（χ^2=13.89-14.97,P〈0.05）。结论 联合检测血清TK1、CA153、CEA对乳癌的诊断具有重要临床价值。Objective To assess the clinical value of combined detection of thymidine kinase 1 （TK1）, carcinoma antigen 153 （CA153） and caricinoembryonic antigen （CEA） in diagnosis of breast cancer. Methods TK1, CA153 and CEA were detec ted by chemiluminescence in serum of 216 patients with benign breast tumor, 105 with breast cancer and 100 healthy controls. Results TK1, CA153 and CEA levels in breast cancer were higher than that in patients with benign breast diseases and in the nor mal controls （F=3.38-3.62 ,P〈0.05）. Compared with individual tests, the combined detection of serum TK1, CA153 and CEA had a higher sensitivity in the diagnosis of breast cancer （x^2 = 13.89- 14.97, P〈0.05）. Conclusion Combined detection of serum TK1, CA153, and CEA has an important clinical value in diagnosing breast cancer.

关 键 词：乳房肿瘤 胸苷激酶 抗原 肿瘤相关 碳水化合物 癌胚抗原 诊断 

分 类 号：R737.9[医药卫生—肿瘤]