阿尔茨海默病精神行为症状与血浆Hcy和叶酸及Vit B_(12)的相关性  

CORRELATION BETWEEN BEHAVIOURAL AND PSYCHOLOGICAL SYMPTOMS AND HOMOCYSTEINE,FOLATE AND VITAMIN B_(12) IN ALZHEIMER DISEASE

作　　者：郑占杰[1] 王金东[1] 孔伶俐[1] 崔维珍[1] 

机构地区：[1]青岛市精神卫生中心,山东青岛266034

出　　处：《齐鲁医学杂志》2015年第1期39-41,共3页Medical Journal of Qilu

基　　金：青岛市卫生局资助项目(2010-WSZD-068)

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)和叶酸、维生素B12(Vit B12)与阿尔茨海默病精神行为症状(BPSD)的相关性。方法对77例阿尔茨海默病病人(其中BPSD组40例,非BPSD组37例)进行血浆Hcy、叶酸及Vit B12测定,以同期常规体检的健康老年人39例作为正常对照组。结果 BPSD组和非BPSD组血浆Hcy明显高于正常对照组(F=199.64,q=19.9、11.4,P<0.01),且BPSD组高于非BPSD组,差异有显著性(q=8.1,P<0.01)。BPSD组和非BPSD组血浆叶酸水平明显低于正常对照组(F=35.17,q=-6.5、-7.8,P<0.05),而BPSD组与非BPSD组比较差异无显著性(q=1.4,P>0.05)。BPSD组及非BPSD组血浆Vit B12水平均明显低于正常对照组(F=350.99,q=-26.0、-17.2,P<0.01),且BPSD组显著低于非BPSD组(q=8.4,P<0.01)。结论Hcy、叶酸和Vit B12水平降低可能参与BPSD的发病。Objective To investigate the correlation between homocysteine, folate, vitamin B12 and behavioural and psychological symptoms of dementia （BPSD）. Methods Homocysteine, folate and vitamin B12 were measured in 77 patients with AZzheimer disease, of whom, 40 in BPSD group, 37 in non-BPSD group, and 39 healthy seniors served as controls. Results The plasma homocysteine levels were significantly higher in BPSD and non-BPSD group than the normal group （F = 199.64;q = 19.9,11.4;P〈0.01）, and the levels of plasma folatc in BPSD group and non-BPSD group were lower than normal controls （F= 35.167;q=-6.5,-7.8;P〈0.05）, but that between the BPSD group and non-BPSD group was not significant （q= 1.4,P〉0.05）. The plasma vitamin B12 levels were significantly lower in BPSD and non-BPSD groups than the normal group （F- 350.99; q = -26.0,- 17.2;P〈0.01）, and that in the BPSD group was significantly lower than non-BPSD group （q=8.4,P〈0.01）. Conclusion Decrease of level of hyperhomocysteine, folate and vitamin B12 is probably involved in the pathogenesis of behavioural and psychological symptoms of dementia.

关 键 词：阿尔茨海默病 痴呆的精神和行为症状 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R749.2[医药卫生—神经病学与精神病学]