Microwave-assisted,facile,rapid and solvent-free one pot two-component synthesis of some special acylals  

作　　者：Yu-Heng Ma Gang Wu Nan Jiang Shu-Wang Ge Qian Zhou Bai-Wang Sun 

机构地区：[1]School of Chemistry and Chemical Engineering,Southeast University [2]Nanjing SimnovTecPharmaceuticals [3]School of Pharmacy,Nanjing Medical University

出　　处：《Chinese Chemical Letters》2015年第1期81-84,共4页中国化学快报（英文版）

摘　　要：A facile, rapid and solvent-flee method for the conversion of acids and dihalomethane to the corresponding methylene diesters （acylals） using microwave as activators or assistor, is reported. This method is particularly powerful for the diesterification of carboxylic acids, which afford methylene diesters in good to excellent yields （up to 〉99%）. When the intermediate is trapped, a ＂double successive SN2 reactions＂ mechanism is proved.A facile, rapid and solvent-flee method for the conversion of acids and dihalomethane to the corresponding methylene diesters （acylals） using microwave as activators or assistor, is reported. This method is particularly powerful for the diesterification of carboxylic acids, which afford methylene diesters in good to excellent yields （up to 〉99%）. When the intermediate is trapped, a ＂double successive SN2 reactions＂ mechanism is proved.

关 键 词：Double successive SN2 reactions Acylal ANILINES Methylene diester 

分 类 号：O621.3[理学—有机化学]