低氘水抗肿瘤作用的研究进展及其可能机制  

Research progress and the possible mechanisms of the inhibitory effect of deuterium-depleted water on cancers

作　　者：陈淼[1] 刘光甫[2] 陈楚言 杨慧龄[2] 祝葆华[2] 

机构地区：[1]广东医学院附属医院肝胆外科,广东湛江524023 [2]广东医学院中美肿瘤研究所,广东东莞523808

出　　处：《中国医药导报》2015年第4期155-158,F0003,共5页China Medical Herald

基　　金：国家自然科学基金项目(编号81272334);广东省东莞市高等院校科研机构科技计划重点项目[编号:东科(2012)123号];广东医学院博士基金项目(编号GK1005)

摘　　要：饮用低氘水可以预防疾病、延缓衰老、活化机体免疫细胞,特别是对某些癌症等疾病的辅助治疗,是近年国外核医学领域和水生理学领域对低氘水研究的重大突破。目前,抗癌化疗药物仍是肿瘤的重要治疗手段,但其毒副作用强,易导致多药耐药的产生,而低氘水使用方便,无毒副作用,且可能对肿瘤的多药耐药逆转有巨大作用。其抗癌机制极其复杂,故本文对低氘水抗肿瘤作用的研究进展及其可能机制做一综述。Drinking deuterium-depleted water can conduce to disease prevention, senility delay and activation of immune cells, especially for certain types of cancer and other diseases, its effect of adjunctive therapy has been a significant breakthrough in the field of nuclear medicine and water-physiology in recent years. Currently, anticancer chemotherapeutic agents remain an important treatment; nevertheless, toxic and side effects of them are quite common.Moreover, multidrug resistance will be easily led by chemotherapeutic agents. Deuterium-depleted water, by contrast,has little toxic and side effects, and may play a significant role in reversing multidrug resistance of tumor. The anti-cancer mechanism of deuterium-depleted water is complex and intricate, and therefore this paper reviews the research progress and possible mechanism of its anticancer effect.

关 键 词：低氘水 抗肿瘤 机制 

分 类 号：R733[医药卫生—肿瘤]