脑实质内神经鞘瘤临床病理分析  

Clinicopathological analysis of parenchymal schwannoma

作　　者：欧阳小明[1] 梅开勇[1] 郝卓芳[1] 唐甜[1] 廖德贵[1] 

机构地区：[1]广州医科大学附属第二医院病理科,510260

出　　处：《中华临床医师杂志（电子版）》2015年第3期52-54,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨脑实质内神经鞘瘤的临床病理特征、免疫组化表型和鉴别诊断。方法报道1例罕见的脑实质内神经鞘瘤,并结合文献对其临床资料、病理特征、免疫组化表型及治疗和预后等进行分析。结果患者年龄44岁,肿瘤为单发,境界清楚。镜下肿瘤细胞呈梭形,形态温和,细胞排列呈栅栏状,可见典型Antoni A区和Antoni B区,未见核分裂象。免疫组化结果:S-100(+++),Vimentin(+),GFAP(灶+),Nestin(灶+),CK(-),EMA(-),Syn(-),NF(-),CD34(-),BCL-2(-),CD99(-),Neu N(-),Ki-67(2%+)。结论脑实质内神经鞘瘤发病罕见,较易误诊为转移瘤,诊断主要依靠组织形态学特征,影像学表现、免疫组化有助于和其他肿瘤鉴别诊断。手术完整切除可治愈。患者随访两年预后良好。Objective To investigate the clinicopathological features, immunohistochemical phenotype and differential diagnosis of parenchymal schwannoma. Methods Reported one case of brain parenchyma schwatmorna. The clinical data, pathological features, immunohistochemical phenotype, treatment and prognosis was analyzed in this tumor. Results A 44-years-old female with a single tumor in brain was reviewed. The tumor was composed of spindle cells, with mild morphology, arranging in palisade, showing typical AntoniA area and AntoniB area, and no mitotic figures by microscope. Immunohistochemical results： S-100（＋＋＋）, Vimentin（＋）, GFAP（＋）, Nestin（＋）, CK（-）, EMA（-）, Syn（-）, NF（-）, CD34（-）, BCL-2（-）, CD99（-）, NeuN（-）, Ki-67（2%＋）. Conclusion Schwannoma of brain parenchyma is rare case, it is easier to be misdiagnosed as metastatic tumor. The diagnosis of this tumor mainly depends on histological features, imaging findings and irnmtmohistochemistry. Complete surgical resection is the best way to cure it. Patients followed up for two years have good prognosis.

关 键 词：神经鞘肿瘤 免疫组织化学 脑实质 

分 类 号：R739.4[医药卫生—肿瘤]