喹硫平和氟哌啶醇治疗谵妄的临床疗效和安全性Meta分析  

Quetiapine versus haloperidol in treatment of patients with delirium: a Meta-analysis

作　　者：肖骋 肖劲松[1] 李华钢[1] 刘汉兴[1] 施余露[1] 

机构地区：[1]武汉大学中南医院神经内科,430071

出　　处：《中华临床医师杂志（电子版）》2015年第3期96-99,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的评价新型抗精神病药喹硫平和氟哌啶醇治疗谵妄的临床疗效和安全性。方法计算机检索Embase、Pubmed、中国知网全文数据库、万方数据库2000年1月至2014年10月有关喹硫平和氟哌啶醇治疗谵妄的随机对照试验,并进行Meta分析。结果共纳入3篇关于两种药物治疗谵妄的随机对照试验和1篇前瞻性非随机对照研究。Meta分析显示喹硫平对谵妄患者谵妄评定量表(DRS)评分和临床整体印象量表严重程度评分(CGI-SI)的改善与氟哌啶醇组无统计学差异。喹硫平和氟哌啶醇的锥体外系副反应无统计学差异。结论喹硫平治疗谵妄的疗效和安全性基本与氟哌啶醇相似。由于本Meta分析的存在一定方法学的局限性,还需要更多的含有良好设计方法、样本量足够、高质量的多中心随机对照试验来印证本研究结果的可靠性。Objective To evaluate the clinical efficacy and safety ofquetiapine and haloperidol in treatment of patients with delirium. Methods We searched in Embase, Pubmed, WanFang database and CNKI to identify studies on prospective trials about quetiapine and haloperidol in treatment of patients with delirium from January 2000 to October 2014. A Meta-analysis was performed. Results 3 RCTs and one prospective observational study were included. There was no significant difference in improvement of DRS and CGI-SI scores of delirious patients between quetiapine and haloperidol group; no significant difference in incidence rate of adverse effects in extrapyramidal system between two groups （P〈0.05）. Conelusion Quetiapine and haloperidol were equally efficacious and safe in the treatment of delirium. However, double-blind, randomized and multi-center studies are needed.

关 键 词：谵妄 氟哌啶醇 META分析 喹硫平 

分 类 号：R749[医药卫生—神经病学与精神病学]