化疗对机体免疫细胞的调节  

Regulation of chemotherapy on immune cells

作　　者：李海燕[1] 苏文[2] 

机构地区：[1]山西医科大学第二临床医学院,太原030001 [2]山西省肿瘤医院免疫室免疫治疗中心,太原030013

出　　处：《中华临床医师杂志（电子版）》2015年第3期109-112,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省科技基础条件平台建设项目(2011091022);山西省大型科学仪器升级改造项目(晋财预2013-73)

摘　　要：肿瘤的发生、发展及转移与机体的免疫细胞的功能密切相关,到目前为止,肿瘤的治疗方法仍然以化疗为主,以往的研究一直认为化疗在杀伤肿瘤细胞的同时,抑制了机体的免疫系统,近期一系列研究证明化疗药物通过降低Treg细胞的数量,诱导树突状细胞(DC)成熟等增强机体免疫细胞功能的途径而提高机体抗肿瘤的作用,根据化疗后免疫细胞功能的变化,优化化疗联合免疫治疗方案,这为化疗联合免疫治疗带来了新的突破点,本文综述常见化疗药物对机体免疫细胞功能的影响。The development and metastasis of tumor is closely related to the function of the body＇s immune cells, so far, the treatment of tumor is still given priority to cheraotherapy, previous studies have argued that chemotherapy can kill tumor cells, at the same time, it inhibits the body＇s immune system, a series of recent studies have shown that chemotherapy drugs by reducing the number of Treg ceils, induced DC mature and other ways to enhance the body＇s immune cell function and improve the body＇s anti-tumor effect, according to the change of the function of immune cells after chemotherapy, sehemotherapy combined immunotherapy and optimization scheme brought new breakthrough for chemotherapy combined immunotherapy, this paper reviewed effect of common chemotherapy drugs on the body＇s immune cell function.

关 键 词：肿瘤 免疫细胞 化疗药物 免疫治疗 

分 类 号：R730.5[医药卫生—肿瘤]