磷脂酰肌醇3激酶/蛋白激酶B信号通路与神经退行性疾病  

PI3K / Akt signal pathway and neurodegenerative diseases

作　　者：伍霞[1] 井秀娜[1] 陶恩祥[1] 

机构地区：[1]中山大学孙逸仙纪念医院老年神经,广州510120

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第1期54-58,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：国家自然科学基金资助课题(81371391);广东省自然科学基金资助课题(S2012010010731)

摘　　要：神经退行性疾病是中枢神经系统内神经元结构和功能进行性丢失导致神经元死亡的一类疾病,常见的包括阿尔茨海默病(AD)、帕金森病(PD)、亨廷顿病(HD)和肌萎缩侧索硬化(ALS)。磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号通路是细胞内重要的促生存信号通路,广泛存在于各种细胞。在生长因子、细胞因子及其他外界刺激下该通路被激活,调节细胞增殖、分化、生长、存活、代谢、迁移、膜转运等多种细胞生物学活动。近来研究发现,PI3K/Akt信号通路异常可能是AD、PD、HD和ALS等神经退行性疾病发病的基础。Neurodegenerative diseases are a family of disorders characterized by progressive loss of neuronal function and structure, resulting in neuronal death in the nervous system. The most common are Alzheimer＇s disease （ AD）, Parkinson＇ s disease （ PD）, Huntington＇ s disease （ HD ）, and amyotrophic lateral sclerosis（ ALS ）. The phosphatidylinositol-3-kinase/protein kinase B （PI3K/Akt）signaling pathway which plays an important role in cellular pro-survival activity is widely involved in various types of cells. The PI3K/ Akt pathway has been implicated in diverse biological events such as proliferation, growth, division, survival, metabolism,migration and membrane trafficking when activated under growth factors and cytokines or other excellular stimulations. Recent studies have suggested that disregulation of PBK/Akt signaling pathway maybe the basis of neurodegenerative diseases including AD,PD, HD and ALS.

关 键 词：磷脂酰肌醇3激酶/蛋白激酶B信号通路 神经退行性疾病 神经保护 

分 类 号：R741[医药卫生—神经病学与精神病学]