嗅神经母细胞瘤临床病理特征并文献复习  

Clinicopathologic Characteristics of Olfactory Neuroblastoma: a Literature Review

作　　者：王晶晶[1] 许春伟[1] 刘翠[1] 张博[1] 邵云[1] 王怀涛[1] 吴永芳[1] 李晓兵[1] 刘甲子[1] 

机构地区：[1]军事医学科学院附属医院病理科,北京100071

出　　处：《解放军医药杂志》2014年第12期90-94,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨嗅神经母细胞瘤的临床病理学特点及诊断要点。方法对我院收治的1例嗅神经母细胞瘤患者的临床资料、病理形态学及免疫组化特点进行分析,并结合文献对其诊断及鉴别诊断进行探讨。结果本例镜下见肿瘤细胞大小一致,为小细胞,细胞质稀少,核膜和背景不清楚,呈明显的纤维状和网状。间质中有丰富的血管,肿瘤细胞被间质分隔成团。免疫组化染色显示:CK(+),EMA(+),Syn(+),NSE(+),LCA(-),CK5(-),CK7(-),NF(-)和Melan A(-)。结论嗅神经母细胞瘤非常罕见,提高对该病临床病理特点的认识,临床可减少误诊。Objective To explore the clinicopathologic characteristics and diagnostic criteria of olfactory neuro- blastoma. Methods The clinical data, pathomorphology and immunohistoehemical characteristics of one patient with ol- factory neuroblastoma were analyzed, and its diagnosis and differential diagnoses combined with literature were studied. Results The biopsy tissue under microscopic examination showed that the tumor cells were small cells with an identical size, scarce cytoplasm, the nuclear membrane was not clear, and background was unclear with obvious fibrous and reticu- late. Abundant blood vessels were found in interstitial substance, and the tumor cells were separated into groups by inter- stitial substance. Immunohistochemical staining showed that tumor cells were CK （ ＋ ） , EMA （ ＋ ） , Syn （ ＋ ） , NSE （＋）, LCA（-）, CK5（-）, CK7（-）, NF（-） and MelanA（-）. Conclusion Olfactory neuroblastoma is very rare, therefore clinicians should raise awareness of the disease in order to avoid misdiagnosis.

关 键 词：成感觉神经细胞瘤 嗅觉 病理学 临床 免疫组化 

分 类 号：R730.264[医药卫生—肿瘤]