烟草生物反应器生产药用蛋白的研究进展  

Research Advances in Tobacco Bioreactor for Production of Therapeutic Proteins

作　　者：闫宁[1] 刘艳华[1] 张忠锋[1] 

机构地区：[1]中国农业科学院烟草研究所,山东青岛266101

出　　处：《中国农学通报》2014年第31期57-63,共7页Chinese Agricultural Science Bulletin

基　　金：中国农业科学院科技创新工程"烟草功能成分与综合利用"团队

摘　　要：总结了烟草生物反应器生产药用蛋白的3种类型,归纳了细胞核表达、叶绿体表达以及瞬时表达等外源重组蛋白的表达体系,重点阐述了利用烟草表达自身抗原的口服免疫耐受诱导,进而提出了烟草生物反应研究存在的问题与解决方法。通过上述分析,对下一步利用烟草生物反应器生产药用蛋白及其在中国烟草控制规划中的应用前景进行了展望。This article reviewed three main kinds of therapeutic proteins produced by tobacco bioreactors,concluded the expression systems producing exogenous recombinant protein including nuclear expression,chloroplast expression and transient expression, and highlighted oral tolerance induction using tobacco expressing autoantigens, accordingly this article raised the problems to be solved in tobacco bioreactor research and the solutions. From above analysis, prospect was made for further improvement of tobacco bioreactor for production of pharmaceutical proteins and its application in China＇s tobacco control programs.

关 键 词：生物反应器 烟草植株 药用蛋白 口服免疫耐受 表达体系 

分 类 号：S188[农业科学—农业基础科学]