血管紧张素原基因多态性及血糖水平与动脉硬化性脑梗死的相关性  

Correlation among angiotensinogen gene polymorphisma,blood glucose level and atherosclerotic cerebral infarction

作　　者：李宏芬[1] 沈志霞[1] 刘子洪[2] 王颖杰[1] 安洁[3] 任燕[1] 

机构地区：[1]开滦总医院检验科,河北唐山063000 [2]开滦总医院骨外科,河北唐山063000 [3]开滦总医院营养科,河北唐山063000

出　　处：《国际检验医学杂志》2014年第24期3364-3365,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血管紧张素原(AGT)基因T174M、M235T多态性及血糖水平与动脉硬化性脑梗死的关系。方法采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测AGT基因T174M、M235T位点基因型的多态性,用全自动生化分析仪测定血糖等生化指标。结果 AGT基因T174M位点携带TT基因型者、TM基因型者ACI组GLU水平高于健康对照组有统计学差异(P<0.05),两组不同基因型间血糖水平比较差异无统计学意义(P>0.05);M235T位点MM、MT、TT基因型者ACI组GLU水平高于健康对照组比较差异有统计学意义(P<0.05),两组不同基因型间血糖水平比较差异无统计学意义(P>0.05)。结论血管紧张素原(AGT)基因T174M、M235T多态性及血糖水平与动脉硬化性脑梗死三者之间未发现关联性;高血糖是动脉硬化性脑梗死的发生的危险因素之一。Objective To study the relationship among the angiotensinogen （AGT）gene T174M,M235T polymorphisma,blood glucose level and atherosclerotic cerebral infarction.Methods The polymerase chain reaction-restriction fragment length polymor-phism （PCR-RFLP）method was adopted to detecte the gene polymorphisms of AGT gene 174,235 sites and the fully automatic bi-ochemical analyzer was used to detect the biochemical indexes of GLU,etc.in 396 patients with atherosclerotic cerebral infarction and 360 normal controls.Results The GLU level in the patients of the ACI group carrying genotype TT and TM at AGT gene T174M site was higher than that in the normal control group with statistical differences（P 〈0.05）,the glucose level had no statisti-cal difference between the different 2 kinds of genotype （P 〉0.05）;the glucose level in the patients carrying genotypes MM,MT and TT at M235T site in the ACI group was higher than that in the normal group,and the difference was statistically significant（P〈0.05）.The blood glucose level between the two groups carrying 2 different kinds of genotype showed no statistically significant difference （P 〉0.05 ）.Conclusion No correlation is found among AGT gene T174M,M235T polymorphism,blood glucose level and atherosclerotic cerebral infarction;hyperglycemia is one of the risk factors of atherosclerotic cerebral infarction occurrence.

关 键 词：动脉硬化性脑梗死 血管紧张素原 基因多态性 血糖 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R440[医药卫生—临床医学]