平均血小板体积在胃癌早期诊断中的应用价值  

The Value of Mean Platelet Volume in Early Diagnosis of Gastric Cancer

作　　者：李伟[1] 吴梦瑶[1] 练炼[2] 殷红[1] 陶敏[1] 

机构地区：[1] 苏州大学附属第一医院肿瘤科,江苏苏州215006 [2] 苏州市相城人民医院肿瘤科,江苏苏州215131

出　　处：《中国血液流变学杂志》2014年第2期212-214,共3页Chinese Journal of Hemorheology

基　　金：国家自然科学基金资助项目(81472296，81272542，81101867)；江苏省卫生厅医学科研项目(Z201206)；中华国际医学交流基金会专项基金项目(CIMF-F-H001-057)；吴阶平医学基金会临床科研专项资助基金项目

摘　　要：目的：探讨平均血小板体积（mean platelet volume, MPV）作为胃癌早期诊断指标的应用价值。方法回顾52例胃癌根治术患者术前，及术后2周的血常规检测结果，同时招募52名年龄、性别相匹配的健康志愿者作为对照纳入研究。分析胃癌患者MPV水平与临床病理特征的相关性；胃癌患者术前及术后MPV水平的差异；以及胃癌患者术前、术后的MPV水平与健康志愿者的差异。结果胃癌患者MPV水平与性别、年龄、肿瘤大小、淋巴结转移、肿瘤分级均无明显相关性（P＞0.05）；胃癌患者术前MPV水平与对照组差异有统计学意义（8.41±0.58 fL vs.7.68±0.56 fL，P＜0.001）；胃癌患者术前与术后的MPV水平差异有统计学意义（8.41±0.58 fL vs.7.65±0.53 fL，P＜0.001）；胃癌患者术后MPV水平与对照组差异无统计学意义（7.65±0.53 fL vs.7.68±0.56 fL，P=0.720）。结论 MPV有可能应用于胃癌高危人群的早期诊断。Objective To investigate the application of mean platelet volume （MPV） in the early diagnosis of gastric cancer. Methods 52 gastric cancer patients and 52 age-sexes matched healthy subjects were enrolled in this study. MPV level of gastric cancer patient was tested pre-operation and 2 weeks after operation. MPV levels were compared between pre-and post-operative samples. The pre-and post-operative MPV levels were also compared with the MPV level obtained from healthy subjects respectively. Results MPV level was significantly higher in pre-operative gastric cancer patients compared to healthy subjects （8.41±0.58 fL vs. 7.68±0.56 fL, P〈0.001）. The MPV level decreased significantly 2 weeks after operation （8.41±0.58 fL vs. 7.65±0.53 fL, P〈0.001）. There was no significant difference in MPV levels of post-operative patients and healthy subjects （7.65±0.53 fL vs. 7.68±0.56 fL, P=0.720）. Conclusion Changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients bearing gastric cancer risks and may contribute to the early diagnosis of gastric cancer.

关 键 词：平均血小板体积 胃癌 早期诊断 

分 类 号：R735.2[医药卫生—肿瘤]