斑蝥酸钠维生素B_6联合同步放化疗治疗中晚期宫颈癌的观察  

Clinical observation on sodium santharidinate and vitamin B_6 injection combined with concurrent radiochemotherapy for advanced cervical cancer

作　　者：蒋宏玲[1] 黄辉[2] 刘美莲[2] 陈秋秋[2] 张荣君[2] 

机构地区：[1]桂林医学院附属医院康复科,广西桂林541001 [2]桂林医学院附属医院放疗科,广西桂林541001

出　　处：《华夏医学》2014年第6期89-92,共4页Acta Medicinae Sinica

基　　金：广西中医药管理局科研项目(GZZC14-66)

摘　　要：目的:观察斑蝥酸钠维生素B6注射液联合同步放化疗治疗中晚期宫颈癌患者的疗效。方法:84例中晚期宫颈癌患者随机分为A、B两组,A组43例,在同步放化疗基础上加用斑蝥酸钠维生素B6注射液0.5mg,1次/d,至放疗结束;B组41例,采用同步放化疗。结果:A组完全缓解(CR)率为69.77%,B组完全缓解(CR)率为43.90%,差异有统计学意义(P<0.05);A组生活质量Karnofsky评分高于B组,差异有统计学意义(P<0.05);A组骨髓抑制、胃肠道反应明显低于B组,差异均有统计学意义(P<0.05)。结论:斑蝥酸钠维生素B6注射液联合同步放化疗治疗中晚期宫颈癌,能提高肿瘤完全缓解(CR)率,改善患者的生活质量,降低放化疗对患者的不良反应。Objective To evaluate the effect of sodium santharidinate and vitamin B6 injection com- bined with concurrent radiochemotherapy for the advanced cervical cancer patients. Methods A to- tal of 84 patients with cervical cancer were randomized into Group A （n=43） and B （n=41）. Group A received radiochemotherapy together with sodium santharidinate and vitamin B6 injection at a dose of 0.5 mg 1 time/d qd while Group B received only radiochemotherapy. Results. There was significant difference in the complete remission （CR） rate between Group A and Group B （69.77% vs. 43.90%, P〈0.05）. The Karnofsky score of life quality was significantly higher in Group A than that in Group B, showing significant difference between the two groups （P〈0.05）. And the haematologic toxicities and gastrointestinal reactions were significantly milder in Group A than that in Group B, indicating that there was significant difference （P〈0.05）. Conclusion. Sodi- um santharidinate and vitamin B6 injection added with concurrent radiochemotherapy for the ad- vanced cervical cancer patients can improve the CR rate and the patient＇s quality of life, and attenu-ate the adverse reactions caused by radiochemotherapy.

关 键 词：宫颈癌 同步放化疗 斑蝥酸钠维生素B6注射液 生活质量 不良反应 

分 类 号：R737.33[医药卫生—肿瘤]