惊恐障碍患者病理生理特性与血浆脑源性神经营养因子水平的相关性  

The relationship between pathophysiologic traits and plasma brainderived neurotrophic factor in patients with panic disorder

作　　者：曹红子[1] 千永日[2] 

机构地区：[1]延边大学附属医院 [2]延边大学医学院,吉林延吉133000

出　　处：《延边大学医学学报》2014年第3期202-204,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]观察惊恐障碍患者病理生理特性与血浆脑源性神经营养因子(BDNF)水平的相关性.[方法]随机选取110例惊恐障碍患者,采用Panic Disorder Severity Scale,Acute Panic Inventory判定惊恐障碍程度,利用酶联免疫吸附测定法检测血浆BDNF质量浓度,比较惊恐障碍程度与血浆BDNF水平之间的相关性.[结果]惊恐障碍患者血浆BDNF质量浓度较正常对照组显著降低(F=80.50,P<0.001);发病6个月内有生活应激事件的惊恐障碍患者血浆BDNF质量浓度较无应激事件患者显著增高(P<0.05).[结论]血浆BDNF质量浓度降低可能与惊恐障碍患者的病理生理变化相关.OBJECTIVETo investigate the relationship between the pathophysiologic traits and plasma brain-derived neurotrophic factor（BDNF）in patients with panic disorder.METHODS110 patients with panic disorder were selected.The severity of panic disorder was measured by panic disorder severity scale and acute panic inventory,and the concentration of plasma BDNF was detected by ELISA,and the correlation between the severity of panic disorder and plasma BDNF level was estimated.RESULTSThe mean concentration of plasma BDNF was significantly lower in patients with panic disorder than in control group（F=80.50,P〈0.001）,and was significantly higher in panic patients with the history of recent stressful life events attacked in 6 months than in control group without the history（P 0.05）.CONCLUSION Low concentration of plasma BDNF may play an important role in the change of pathophysiology in patients with panic disorder.

关 键 词：惊恐障碍 脑源性神经营养因子 病理生理变化 

分 类 号：R749.7[医药卫生—神经病学与精神病学]