癌症患者死亡前6个月LDH的变化情况及临床意义  

The change of LDH values and its clinical significance in cancer patients' last 6 months of life

作　　者：饶洁[1] 姜永生[1] 沈倩[1] 孙越[1] 任辉[1] 周婷[1] 于世英[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤中心,武汉430030

出　　处：《癌症进展》2014年第5期488-491,共4页Oncology Progress

摘　　要：目的明确癌症患者死亡前6个月乳酸脱氢酶(lactate dehydrogenase,LDH)水平的变化趋势,评估LDH水平对患者预后和生存时间是否具有预测性。方法回顾性分析216例癌症死亡患者的一般情况和疾病特征与LDH水平之间的相关性。结果越临近死亡,癌症患者的LDH水平越高,患者的性别、年龄、肿瘤类型和分期与LDH水平之间的相关性无统计学意义(P>0.05)。结论 LDH水平的升高预示了癌症患者不良预后和有限的生存时间。Objective To find out the change trend of LDH values in cancer patients＇ last 6 months of life, and to evaluate whether LDH level was a predictor for on patients＇ prognosis and survival time. Method A retrospec- tive analysis including 216 patients was conducted to assess the correlation between their demographic characteris- tics, disease characteristics and the level of LDH. Results Patients that were closer to death had higher LDH level. In addition, the correlation between patients＇ gender, age, tumor type, tumor stage and LDH levels was insignificant （P 〉 0.05）. Conclusion The increase of LDH level indicates poorer prognosis and limited survival time in cancer patients.

关 键 词：LDH 癌症 生存时间 预后 

分 类 号：R730.4[医药卫生—肿瘤]