白介素1β基因多态性与新疆维吾尔族人群抑郁症的相关性研究  

Relationship between Interleukin 1β Polymorphism and Depressive Disorder among Uighurs in Xinjiang

作　　者：胡楠楠[1] 傅松年[1] 王江涛[1] 党海红[1] 

机构地区：[1]新疆医科大学第一附属医院心理医学科,新疆乌鲁木齐市830054

出　　处：《中国全科医学》2014年第30期3558-3561,共4页Chinese General Practice

基　　金：新疆维吾尔自治区自然科学基金资助项目(2011211A081)

摘　　要：背景维吾尔族有独特的遗传背景,其抑郁症易患基因表达可能与其他民族存在着很大的差异。细胞因子在抑郁症的发病机制中起重要作用,细胞因子基因多态性可能通过影响细胞因子的产生导致神经内分泌的改变从而引起抑郁症状。寻找白介素1β(IL-1β)基因中可能具有抑郁症易患性的单核苷酸多态性(SNP)位点,探讨维吾尔族抑郁症潜在致病基因的差异,为寻求诊断、个体化治疗和预防提供更广的思路。目的探讨IL-1β基因rs1143634和rs3136558位点多态性与新疆维吾尔族抑郁症的相关性。方法选取2012年1月—2013年10月在新疆医科大学第一附属医院心理医学科住院的维吾尔族抑郁症患者100例为抑郁症组,体检中心无精神疾病史、无精神病药物治疗史、无物质滥用史、无神经系统疾病或损伤史者120例为对照组,采用聚合酶链反应-限制性片段长度多态性方法检测受试者IL-1β基因rs1143634和rs3136558位点基因型和等位基因频率分布情况。结果抑郁症组和对照组rs1143634位点和rs3136558位点CC、CT和TT基因型分布比较,差异无统计学意义(P>0.05);C和T等位基因频率比较,差异亦无统计学意义(P>0.05)。结论 IL-1β基因rs1143634和rs3136558位点基因多态性与新疆维吾尔族抑郁症的发生无明显相关性。Background Uygur population has a unique genetic background,the susceptibility gene for depressive disorder of Uygur population may differ from that of other races. Cytokines play an important role in the pathogenesis of depressive disorder. The polymorphism of cytokines may affect the production of cytokines,thus neuroendocrine changes and depressive symptoms occur. Exploring the suspect SNPs in the IL- 1β gene and discussing the race differences for depressive disorder potential pathogenic genes between Uygur and other races may contribute to the diagnosis,individual treatment and prevention for depressive disorder. Objective To explore the relationship between IL- 1β gene rs1143634,rs3136558 site polymorphism and depressive disorder among Uighurs in Xinjiang. Methods A total of 100 Uighurs with depressive disorder who were admitted to department of psychological medicine,the First Affiliated Hospital of Xinjiang Medical University,were selected as depressive disorder group,and 120 physical examinees without history of mental illness,psychiatric medications,drug abuse,nervous system diseases and injuries were selected as control group. The genotype and allele frequency distribution of IL- 1β gene rs1143634,rs3136558 site were detected by using polymerase chain reaction and restriction fragment length polymorphism（ RFLP- PCR）.Results There was no significant difference in rs1143634,rs3136558 site CC,CT,TT genotype distribution between depressive disorder group and control group（ P〉0. 05）. There was no significant difference in C,T allele frequencies（ P〉0. 05）.Conclusion The findings suggest no significant association was found between IL- 1β gene rs1143634,rs3136558 site polymorphism and depressive disorder among Uighurs in Xinjiang.

关 键 词：抑郁症 白介素1Β 基因 多态性 单核苷酸 维吾尔族 

分 类 号：R749.42[医药卫生—神经病学与精神病学]