洛铂与碘油化疗栓塞联合射频消融术治疗原发性肝癌的近期疗效观察  

Short-term effect of combination of lobaplatin,iodized oil chemoembolization and radiofrequency ablation on treatment of primary hepatic carcinoma

作　　者：刘文导[1] 孟凡喆[1] 梅世伟[1] 郝淑芳[1] 梁晓聪[1] 常钢[1] 

机构地区：[1]广东省中医院介入科,广东广州510120

出　　处：《实用临床医药杂志》2015年第1期107-109,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321469)

摘　　要：目的观察洛铂与碘油化疗栓塞联合射频消融术治疗治疗原发性肝癌的近期疗效。方法对40例原发性肝癌患者行肝动脉栓塞化疗术(TACE),化疗栓塞药物为洛铂+碘化油,对病灶行射频消融。检测治疗前后血清甲胎蛋白(AFP)变化,于4周后评价近期疗效。结果治疗总有效率为80.0%。治疗后AFP值显著下降(P<0.01),16例恢复至正常值。结论洛铂与碘油化疗栓塞联合射频消融治疗原发性肝癌近期效果良好,安全有效。Objective To observe the short-term effect of combination of lobaplatin, iodized oil chemoembolization and radiofrequency ablation on the treatment of primary hepatic carcinoma. Methods Hepatic arterial chemoembolization was applied for 40 patients with unresectable primary hepatic carcinoma. Lobaplatin and iodized oil were used as embolization agents, and then radiofre- quency ablation was used in the lesions. The serum alpha-fetoprotein （AFP） was detected before and after treatment. Four weeks after treatment, the short-term effect was observed. Results The total effective rate was 80.0 %. The AFP values significantly decreased after treatment （P 〈 0.01） and AFP in 16 patents recovered to the normal value. Conclusion Combination of lobaplatin, iodized oil chemoembolization and radiofrequency ablation is an effective and safe method for treat- ment of primary hepatic carcinoma.

关 键 词：原发性肝癌 化疗栓塞 洛铂 碘化油 射频消融 

分 类 号：R735.7[医药卫生—肿瘤]