慢性硬化性涎腺炎的研究进展  

Research progress on chronic sclerosing sialadenitis

作　　者：王班超[1] 史册[1] 方滕姣子 常蓓[1] 丛明宇[1] 孙宏晨[1] 

机构地区：[1]吉林大学口腔医院病理科,长春130021

出　　处：《国际口腔医学杂志》2015年第2期210-215,共6页International Journal of Stomatology

摘　　要：慢性硬化性涎腺炎(CSS)是一种常累及单侧或双侧下颌下腺,表现为坚韧的痛或无痛性肿块的慢性涎腺炎症,多发于成年男性。其病机可能与基因易患性和异常免疫反应有关。实验室检查示IgG4升高。CSS特异性的病理组织学改变为富含细胞的纤维组织增生,形成具有明显不规则形状生发中心的淋巴滤泡,其中以IgG4阳性的浆细胞大量浸润为主要诊断依据。糖皮质激素被认为是针对IgG4相关性疾病最有效的药物,但其治疗后的复发率较高。该病已有逾百年的历史,但其病机、诊断标准和有效地治疗等仍无定论,相信随着该病越来越广泛和深入的研究,上述问题会逐渐得以解决。Chronic sclerosing sialadenitis（CSS） is a kind of chronic sialadenitis, frequently involved unilateral or bilateral submandibular giand, manifested as tough pain or painless mass, and it is multiple in adult male. Its pathogenesis may be related to genetic predisposition and abnormal immune response. Laboratory examination showed the increased IgG4. CSS specific pathological features are proliferation of cellulous fibrous tissue, formation of lymphoid follicles with obvious irregular shape of the germinal centers, and a large number of IgG4 positive plasma cells infiltration is its main diagnosis basis. Glucocorticoid is considered to be the most effective drugs against the IgG4 related disease, but the recurrence rate of the treatment is high. The disease has more than a hundred years of history, but its pathogenesis, diagnosis standard and effective treatment remains uncertain, we believe that with the more widely and deeply research of the disease, the above problems will be solved gradually.

关 键 词：IGG4相关性疾病 IgG4相关性涎腺炎 慢性硬化性涎腺炎 

分 类 号：R781.72[医药卫生—口腔医学]