体检人群超敏C反应蛋白与代谢综合征的相关性研究  

Relationship between high sensitivity C-reactive protein and metabolic syndrome in check-up crowd

作　　者：宋珏[1] 冉利梅[1] 华玉淑[1] 曹煜[1] 莫澜[1] 沈璐[1] 吴春维[1] 詹洁[1] 

机构地区：[1]贵阳医学院附属医院体检中心,贵州贵阳550004

出　　处：《贵州医药》2014年第12期1073-1076,共4页Guizhou Medical Journal

基　　金：贵阳市科技局社会发展与民生科技计划基金[筑科合(2012)103-27号];贵阳市科技局科技特派员计划基金[筑科合(2012)107-22号]资助

摘　　要：目的探讨体检人群超敏C反应蛋白(hs-CRP)与代谢综合征(MS)的关系。方法选取健康体检者中体检数据完整的975例受检者,其中符合MS诊断的277例,采用秩和检验分析MS组与非MS组间的各组分关系,应用Spearman秩相关分析hs-CRP与MS各组分的相关性。结果 MS组HDL-C水平低于非MS组,BMI、SBP、DBP、hs-CRP、TC、TG、LDL-C、FPG、ALT、AST水平均高于非MS组,差异有统计学意义(P<0.05)。不同年龄段人群非MS组与MS组hs-CRP水平均有差异(P<0.05)。肥胖组hs-CRP水平与低体质量组、正常体质量组、超重组比较明显升高(P<0.05)。hs-CRP水平与BMI、TC、TG、FPG、ALT、AST、SBP及DBP呈正相关;与HDL-C呈负相关。结论hs-CRP水平与MS的发生、发展密切相关。Objective To explore the relationship between high sensitivity C‐reactive protein （hs‐CRP） and metabolic syndrome （MS） in the check‐up crowd .Methods The health check‐up results of 975 subjects were retrospectively analyzed ,including 227 MS patients .Relationship of different com‐ponents between MS groups and non‐MS groups was analyzed by Mann Whitney U Test .The associa‐tion of serum level of hs‐CRP and different components of MS were analyzed by Spearman test .Results The HDL‐C levels of MS groups were respectively lower than those of non‐MS groups ,but the counts of BMI ,SBP ,DBP ,hs‐CRP ,TC ,TG ,LDL‐C ,FPG ,ALT and AST were significantly higher than those of non‐MS groups （ P 〈 0 .05） . The hs‐CRP levels between MS groups and non‐MS groups showed statistically significant differences in different age groups （P〈 0 .05） .The hs‐CRP level of o‐besity groups was the highest in all groups ,and showed significant differences .The hs‐CRP levels were positively correlated with BMI ,TC ,TG ,FPG ,ALT ,AST ,SBP and DBP ,and negatively cor‐related with HDL‐C .Conclusion The hs‐CRP level was closed related to the development and progres‐sion of MS .

关 键 词：超敏C反应蛋白 代谢综合征 胰岛素抵抗 

分 类 号：R-33[医药卫生] R589