80例老年缺血性脑卒中后抑郁干预治疗的临床观察  

Clinical observation of intervention treatment on senile patients with post ischemic stroke depression

作　　者：罗方接[1] 李小云[2] 

机构地区：[1]广东省东莞市石龙人民医院神经外科,513200 [2]广东省东莞市石龙人民医院重症监护室,513200

出　　处：《中华全科医学》2015年第3期430-431,503,共3页Chinese Journal of General Practice

摘　　要：目的探讨老年性缺血性脑卒中后抑郁患者进行抗抑郁干预治疗的临床效果及其与神经功能恢复的关系。方法选取80例老年性缺血性脑卒中患者,随机分为2组,对照组采用常规神经内科药物+安慰剂治疗,观察组采用常规神经内科药物+百忧解抗抑郁治疗,治疗10周,于治疗前后评价并比较汉密尔顿抑郁量表(HAMD)评分和改良的爱丁堡斯堪迪纳维亚神经功能缺损评分(SSS)。结果治疗后观察组HAMD评分及SSS评分均明显低于对照组(P<0.05)。观察组HAMD评分与SSS评分呈正相关(P<0.05)。结论老年缺血性脑卒中后抑郁患者在常规治疗的基础上,加用百忧解抗抑郁干预治疗,有助于抑郁状态的改善和神经功能的恢复。Objective To observe the clinical effect of antidepressant intervention in senile ischemic stroke patients with depression, and explore the correlation between intervention effect and recovery of neurological function. Methods Total 80 cases of senile patients with ischemic stroke were randomly divided into control group and observation group, patients in which treated by routine neurology drugs ＋ placebo and routine neurology drugs ＋ prozac for 10 weeks, respectively. The Hamilton Depression Rating Scale（HAMD） score and improved Edinburgh Scandinavia nerve function deficit score（SSS） were evaluated and compared before and after treatment. Results The HAMD and SSS scores were obviously lower in observation group after treatment than those in control group （P 〈 0.05 ）. The HAMD score had positive correlation with SSS score in observation group （ P 〈 0.05 ）. Conclusion It indicated the improvement of depressive state and recovery of neurological function in senile patients with post ischemic stroke depression by Prozac and the conventional therapy.

关 键 词：老年 缺血性脑卒中 干预治疗 神经功能 百优解 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]