不同膀胱灌注疗法预防浅表性膀胱癌术后复发及对血清VEGF影响的临床观察  

The curative effect of different intravesical instillation therapy in the treatment of postoperative superficial bladder cancer patients and serum VEGF levels observation

作　　者：周浴[1] 何敏[1] 贾洪涛[1] 张少峰[1] 甘伟[1] 罗茂华[1] 

机构地区：[1]湖北医药学院附属人民医院泌尿外科,湖北十堰442000

出　　处：《中国现代医学杂志》2015年第4期75-78,共4页China Journal of Modern Medicine

摘　　要：目的研究不同膀胱灌注疗法治疗浅表性膀胱癌术后患者的疗效及对血清VEGF含量的影响。方法将该院泌尿外科接受经尿道电切术的120例浅表性膀胱癌患者纳入研究,根据术后灌注治疗的方法不同分为两组,观察组患者接受改良长期灌注疗法,对照组患者接受短期灌注疗法,比较两组患者尿液中肿瘤标志物水平、复发率、毒副反应以及血清VEGF含量。结果观察组患者尿液中的NMP22、CYFR21-1和BTA含量以及血清中VEGFA、VEGFB和VEGFC的含量低于对照组(P<0.05)。观察组患者的术后复发率低于对照组(P<0.05)。治疗过程中,两组患者的毒副反应发生率无差异(P>0.05)。结论改良长期灌注疗法有助于彻底杀灭肿瘤细胞,降低远期复发率,减弱膀胱癌的血管新生能力,且毒副反应较轻。[ Objective ] To study the curative effect of different intravesical instillation therapy in treating postop- erative superficial bladder cancer patients and its effect on serum VEGF content. [Methods] 120 cases of patients with superficial bladder cancer underwent transurethral resection were enrolled and divided into two groups according to different intravesical therapy. Observation group was treated with improved long-term instillation therapy and control group was treated with short-term infusion therapy. Then tumor marker level in urine, recurrence rate, toxici- ty and serum VEGF content were compared. [Results] Urine NMP22, CYFR21-1, BTA content and serum VEGFA, VEGFB, VEGFC content were lower than those of control group（P 〈0.05）. Recurrence rates of observation group after surgery were lower than those control group （P 〈0.05）. Adverse reaction of two groups had no difference （P 〉0.05）. [ Conclusion ] Improved long-term instillation therapy was helpful to kill tumor cells, reduce the angiogenesis ability and recurrence rate of bladder cancer with less toxicity.

关 键 词：浅表性膀胱癌 膀胱灌注 吡柔比星 血管内皮生长因子 

分 类 号：R737.14[医药卫生—肿瘤]