阿司匹林引发上消化道出血的相关危险因素研究  

Aspirin Causes of Upper Gastrointestinal Bleeding Risk Factor Analysis

作　　者：汝童 付朝霞[1] 王珊珊[1] 李中恕[1] 周婷[1] 郝丽晓 吉宗珊[2] 刘铁夫[1] 

机构地区：[1]哈尔滨医科大学附属第四医院消化内科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第四医院内分泌科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2015年第4期664-667,共4页Progress in Modern Biomedicine

摘　　要：目的:比较由阿司匹林引发上消化道出血的相关危险因素OR值,探讨其引起消化道大出血的相关机制。方法:收集哈医大四院消化内科及心内科2009年5月份至2013年6月份仅口服阿司匹林一种非甾体抗炎药的100例患者,用药过程中引发上消化道出血的49例患者作为研究组,其余未发生消化道出血的51例患者作为对照组,采集现病史、既往史、吸烟史、行凝血常规、Hp检测及胃镜检查,经单因素统计分析筛选出阿司匹林引发上消化道出血的危险因素;通过多元Logistic回归分析得出阿司匹林引发上消化道出血的独立危险因素。结果:年龄>60岁、Hp感染、既往溃疡病史、糖尿病、吸烟的患者在研究组所占比例明显高于对照组,差异具有统计学意义;经多元Logistic回归后表明年龄>60岁、Hp感染、既往溃疡病史、糖尿病患者和阿司匹林引发上消化道出血的OR值具有统计学差异。结论:年龄>60岁、Hp感染、溃疡病史、糖尿病患者是阿司匹林引发上消化道出血的4个独立危险因素。Objective：To compare the OR values of the risk factors that are associated with upper gastrointestinal hemorrhage caused by aspirin.Methods：100 cases of patients who had taken aspirin orally as the only NSAID （non-steroidal anti-inflammatory drug）and hospitalized at Digestive System Department and Cardiology Department of the Fourth Affiliated Hospital of Harbin Medical University were selected,49 cases of whom had upper gastrointestinal bleeding caused by medicine were selected as research group,and the other 51 cases were used as control group.History of present illness,past medical illness,smoking history,coagulation routine,HP testing and gastroscopy were collected to screen out risk factors that led to upper gastrointestinal hermorrhage caused by aspirin through single factor statistical analysis,and to work out the independent risk factors through multiple Logistic regression analysis.Results：Patients at age over 60 or with history of Hp infection,ulceration,diabetes,and smoking took an apparently higher rate in the research group that in the control group,with statistical significance.Through multiple Logistic regression,it was indicated that there was statistical difference among age over 60 or with history of Hp infection,ulceration,diabetes,and the OR value of upper gastrointestinal hermorrhage caused by aspirin.Conclusions：Age over 60,history of Hp infection,ulceration,diabetes are risk factors which lead to upper gastrointestinal hermorrhage caused by aspirin.

关 键 词：阿司匹林 上消化道出血 危险因素 

分 类 号：R573.2[医药卫生—消化系统]