经支气管镜氩离子凝固术治疗伴有咯血的晚期中心型肺癌的临床观察  

Clinical Effect of Argon Plasma Coagulation by Bronchoscope Intervention in Treatment of 60 Cases of Elderly Patients with Central Lung Cancer Combined with Hemoptysis

作　　者：王世寿[1] 蔺景双[1] 崔丽华[1] 冯涛[1] 郝兴亮[1] 

机构地区：[1]胜利油田中心医院呼吸内科,山东东营257000

出　　处：《现代生物医学进展》2015年第5期918-921,共4页Progress in Modern Biomedicine

摘　　要：目的：探讨经支气管镜氩离子凝固术治疗伴有咯血的晚期中心型肺癌的疗效。方法：选取2011年12月-2013年6月期间我院收治的晚期中心型肺癌咯血的患者60例,将其随机分为观察组（30例）和对照组（30例）,观察组给予经支气管镜氩离子凝固术联合全身化疗,对照组给予经支气管镜介入局部用药联合全身化疗,对比两组患者治疗后的临床疗效、24h动脉血气分析、肺功能、止血有效率及治疗后3天、3~7天,7天复发率以及总复发率和不良反应情况。结果：治疗后两组患者的临床症状均得到一定的改善,观察组患者的临床有效率为80.0%（24/30）显著高于对照组的56.7%（17/30）,差异具有统计学意义（P〈0.05）;观察组患者在发热、呼吸困难、咳嗽、胸痛及咯血等方面的症状缓解率均显著高于对照组,比较差异均有统计学意义（均P〈0.05）;治疗后观察组肺功能和24h动脉血气分析各项指标均显著优于治疗前,观察组患者的的以上指标均显著优于对照组,差异均有统计学意义（均P〈0.05）;治疗后观察组患者的止血有效率为100%,显著高于对照组的56.7%（17/30）,且观察组患者术后3天、3~7天,7天复发率以及总复发率均小于对照组,两组止血有效率和总复发率比较差异均有统计学意义（均P〈0.05）;观察组患者不良反应的发生率为10.0%,对照组为13.3%,两组相比无显著差异（P〉0.05）。结论：经支气管镜氩离子凝固术联合全身化疗治疗老年晚期中心型肺癌咯血具有较好的临床疗效,止血迅速有效,且复发率低,能够缓解呼吸道阻塞症状,改善呼吸功能,是一种不错的选择,值得在临床普遍推广与应用。Objective： To investigate the clinical effect of argon plasma coagulation by bronchoscope intervention in treatment of elderly patients with central lung cancer combined with hemoptysis. Methods： 60 cases of late central type lung cancer patients were selected from our hospital during the period from December 2011 to June 2012. Which were randomly divided into the observation group （30cases） and the control group （30 cases）. The patients of the observation group were treated with argon plasma coagulation by broncho- scope intervention combined with systemic chemotherapy, the control group were treated with topic bronchoscopic intervention com- bined with systemic chemotherapy. The clinical efficacy of the two groups, 24h arterial blood gas analysis and pulmonary function, the record bleeding rate after 3 days, 3 to 7 days, 7 days and the total recurrence rate after treatment and the adverse reactions after treatment were compared. Results： After treatment, the clinical symptoms of the patients had certain improvement. The clinical effective rate of the observation group was 80.0% （24/30）, significantly higher than 56.7% （17/30） of the control group, the difference was statistically signifi- cant （P〈0.05）; The remission rates of fever, chest tightness and dyspnea ,cough, chest pain, hemoptysis in the observation group after treatment were significantly higher than that in the control group, the difference was statistically significant （P〈0.05）; After treatment, the 24h arterial blood gas analysis and pulmonary function were all better than before treatment, and the above indicates of the observation group were significantly better than those of the control group, the difference was statistically significant （P〈0.05）; After treatment, the hemostatic effective rate of the observation group was 100%,siguificantly higher than 56.7% （17/30） of the control group. The record bleeding rate after 3 days, 3 to 7 days, 7 days and the total recurrence rate of the observation group w

关 键 词：经支气管镜氩离子凝固术 晚期中心型肺癌 咯血 疗效 

分 类 号：R734.2[医药卫生—肿瘤]