老年急性脑梗死患者颈动脉粥样硬化新危险因素研究  

New Risk Factor for Carotid Atherosclerosis in Elderly Patients with Acute Cerebral Infarction

作　　者：王少颖[1] 王青青[1] 李净兵[1] 朱见文[1] 徐素芝[1] 王莉迪 

机构地区：[1]河北省老年病医院神经内科,河北石家庄050011

出　　处：《河北医学》2015年第3期366-369,共4页Hebei Medicine

基　　金：2011年河北省科技支撑计划项目;(编号:11276133)

摘　　要：目的:研究老年急性脑梗死(ACI)患者颈动脉粥样硬化(CAS)新危险因素,为CAS的防治提供参考。方法:将162例ACI患者根据是否发生CAS分为无斑块组70例,斑块组92例,分别检测血糖、血脂、胆红素、C反应蛋白(CRP)、尿酸(UA)、纤维蛋白原(Fib)浓度,对上述指标与颈动脉内-中膜厚度(IMT)进行Spearman相关性分析。结果:两组血脂、血糖水平比较差异无统计学意义(P>0.05);斑块组总胆红素(TBIL)、间接胆红素(IBIL)浓度低于无斑块组(P<0.05),CRP、UA、Fib浓度高于无斑块组(P<0.05);CRP、UA、Fib浓度与IMT呈正相关(r1=2.84,r2=1.45,r3=1.98,均P<0.05),TBIL、IBIL浓度与IMT呈负相关(r4=-0.74,r5=-1.02,均P<0.05)。结论:老年ACI患者CRP、UA、Fib浓度升高参与了CAS发病与发展的过程,而TBIL、IBIL是IMT增厚的保护性因素。Objective：To study new risk factors for CAS in elderly patients with ACI ,so as to provide reference for prevention and treatment of CAS .Method： 162 patients with ACI were divided into without plaque group （70 cases） and plaque group （92 cases） according to whether occurred CAS or not .Detected blood glucose,blood lipids,bilirubin,CRP,UA,Fib,and spearman correlation analysis of these index and IMT.Result：Lipids,blood glucose level was no significant difference between two groups （ P〉0.05）;TBIL, IBIL concentrations in plaque group were less than those in without plaque group （P〈0.05）, CRP,UA,Fib concentrations were more than those in without plaque group （ P〈0.05）;CRP ,UA,Fib concentration was pos-itively correlated with IMT（r1=2.84,r2=1.45,r3=1.98,all P〈0.05）,TBIL,IBIL concentration was nega-tively correlated with IMT（r4=-0.74,r5=-1.02,both P〈0.05）.Conclusion： CRP,UA,Fib concentration in elderly patients with ACI involved in the CAS onset and development process ,and TBIL,IBIL is a protec-tive factor for IMT.

关 键 词：急性脑梗死 颈动脉粥样硬化 危险因素 颈动脉内-中膜厚度 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R541.4[医药卫生—临床医学]