精神分裂症患者血清非编码小分子RNA-320a及RNA-320b表达的研究  

Expression of serum non-coding microRNA-320a and micro RNA-320b in patients with schizophrenia

作　　者：彭瑛[1] 黄远帅[1] 邓正华[1] 程松[1] 王开正[1] 

机构地区：[1]四川泸州医学院附属医院检验科,646000

出　　处：《临床精神医学杂志》2015年第1期54-55,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨精神分裂症患者血清非编码小分子RNA(miR)-320a、320b的表达。方法:应用实时荧光定量逆转录聚合酶链式反应技术(RT-PCR)检测30例首次发病的精神分裂症患者(发病组)、30例治疗后临床缓解的精神分裂症者(缓解组)和30名正常对照者(健康对照组)血清miR-320a及miR-320b表达水平。结果:发病组和缓解组血清miR-320a和miR-320b表达明显低于健康对照组(P均<0.001),且发病组明显低于临床治愈组(P均<0.05)。结论:精神分裂症患者血清miR-320b和miR-320a表达低,并与病情有关。Objective： To explore the expression of serum non-coding microRNA（ miR）-320 a and miR-320 b in patients with schizophrenia. Method： The levels of serum miR-320 a and miR-320 b were detected by real-time fluorescent quantitative reverse transcription polymerase chain reaction technology（ RT-PCR） in 30first-onset patients with schizophrenia（ onset group）,30 clinical alleviated schizophrenic patients after treatment（ relief group） and 30 normal controls（ healthy controls group）. Results： The levels of serum miR-320 a and miR-320 b were in the onset and relief groups were significant lower than the healthy controls group（ all P〈0. 001）; and the onset group even lower than the relief group（ all P〈0. 05）. Conclusion： The levels of serum miR-320 a and miR-320 b in schizophrenic patients are lower,which maybe correlated with the disease state.

关 键 词：精神分裂症 microRNA-320a microRNA-320b 

分 类 号：R749.3[医药卫生—神经病学与精神病学]