BRCA2的BRC4基元与RAD51相互作用位点的研究进展  

Research progresses on the interaction sites between BRC4 motif of BRCA2 and RAD51

作　　者：赵东欣[1] 李林彬[1] 卢奎[1,2] 马丽[1] 何娟[1] 

机构地区：[1]河南工业大学化学化工学院,郑州450001 [2]河南工程学院,郑州451191

出　　处：《生命科学》2015年第2期198-202,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(21172054);郑州市创新型科技人才队伍建设工程资助项目(10LJRC174);河南省教育厅科学技术研究重点项目(13B150947)

摘　　要：乳腺癌易感基因2(breast cancer susceptibility gene 2,BRCA2),是人体内一种与乳腺、卵巢、胰腺等部位的肿瘤有关的抑癌基因。人的RAD51(h RAD51)是参与DNA同源重组修复过程的关键蛋白。BRCA2蛋白通过其结构中8个高度保守的BRC重复基元来调控h RAD51通过同源重组对DNA损伤进行的修复,从而阻止细胞癌变。在BRCA2的8个BRC重复基元中,BRC4与同源重组酶h RAD51的相互作用较为明显。综述了BRCA2的BRC4基元与h RAD51相互作用位点的研究进展,为了解BRCA2与RAD51相互作用的分子机理提供基础。Breast cancer susceptibility gene 2 （BRCA2） is a tumor suppressor gene which is related to different cancers, such as breast, ovarian, pancreatic cancer. Human RADS1 （bRADS1） protein plays a crucial role in homologous recombination. BRCA2 interacts directly with RAD51 through eight highly conserved BRC motifs and stimulates the exchange of RAD51-mediated DNA strand in DNA double-strand breaks repair. BRC4 motif shows stronger binding ability to human RAD51 than the other BRC repeats. In order to better understand the molecular interactions between BRCA2 and RAD51, the research progresses on the binding sites of BRC4 and hRAD51 were summarized here.

关 键 词：乳腺癌易感基因2 BRC4 RAD51 作用位点 

分 类 号：Q617[生物学—生物物理学] R73[医药卫生—肿瘤]