放射性125I密封籽源瘤内植入治疗老年原发性肝癌近期临床疗效观察  

Short-term Clinical Effect of 125I implantation on the elderly patients with primary liver cancer

作　　者：吉永烁[1] 张宇[1] 朱绫琳[1] 朱君秋[1] 赵洪[1] 

机构地区：[1]复旦大学附属华东医院肿瘤科

出　　处：《老年医学与保健》2015年第1期38-40,49,共4页Geriatrics & Health Care

摘　　要：目的评价放射性粒子治疗老年原发性肝癌的近期临床疗效与安全性。方法回顾性分析接受放射性粒子植入的老年原发性肝癌患者93例，观察治疗前后肿瘤的影像学变化情况，甲胎蛋白（AFP）水平及不良反应情况。结果治疗后肿瘤的体积较治疗前缩小，6m后总体有效率为83．0％（88／106）。AFP水平降低，治疗后2m、4m、6mAFP与治疗前相比，差异有统计学意义。有1例出现穿刺后腹腔内出血，保守治疗后好转，出现1级急性放射性损伤共3例。结论放射性粒子植入治疗老年原发性肝癌近期临床疗效好，并发症少，是治疗原发性肝癌的有效手段之一。Objective To explore the Short-term clinical efficacy and safety of ^125I implantation on the elderly patients with primary liver cancer. Methods 93 patients with primary liver cancer underwent ^125I seeds brachytherapy were retro- spectively analysed. The local control of tumor size, AFP and complications according to RTOG scoring scale were evaluated and compared before and after treatments. Results The volume of the tumor were significantly reduced. 6 months after treatment, the effective reduction rate of tumor size （CR＋PR） was 83.0% （88/106）. AFP were also significantly reduced. There was no severe adverse reaction except one patient with intraperitoneal bleeding which was controlled by conservative treatments. Conclusion ^125I seeds implantation has a short-term clinical effect and showed less complications, which can be an effective comprehensive therapy for primary liver cancer.

关 键 词：原发性肝癌 ^125I粒子 近距离放疗 

分 类 号：R735.7[医药卫生—肿瘤]