补肾中药淫羊藿修复兔下颌骨缺损影响研究  

Study of Yinyanghuo(Epimedium)on Repair of Mandibular Defects with NanoHydroxyapatite/Collagen/Poly(Lactic Acid)Compound in Rabbits

作　　者：刘艳辉[1] 谢利娜[1] 张晓娟[2] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405 [2]广州中医药大学,广东广州510405

出　　处：《辽宁中医药大学学报》2015年第3期33-35,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广东省中医药局课题(20132130);广东省医学科研基金项目(B2013166)

摘　　要：目的:动态观察补肾中药淫羊藿在兔下颌骨修复过程中的成骨作用。方法:制备16只兔左侧下颌骨10mm×8 mm贯穿性缺损模型,随机分为中药淫羊藿饲养组与对照组。术后2、4、8、12周处死动物,分别从大体、影像学、组织学方面进行观察,计量新骨面积并进行方差分析。结果:影像学观察淫羊藿组2、4、8、12周缺损区密度均高于对照组。组织学观察可见淫羊藿组各时间点骨缺损区新骨形成均优于对照组,新生骨及新生血管的量多。随着时间延长,对组间新骨面积进行方差分析比较,结果显示组间差异有统计学意义。结论:淫羊藿在骨缺损修复期间有良好的促进骨愈合的作用。Objective：To investigate the osteogenesis effect of Yinyanghuo（Epimedium） in bone defects repair. Methods：With the precondition of reserving the periosteum,A 10 mm multiply 8 mm perfoliate defect in mandible was made in each animal. They were randomly divided into 2 groups：the Yinyanghuo（Epimedium）group and control group. At postoperative 2,4,8 and 12 weeks,2 rabbits in each group were sacrificed to make the specimens. The defects were evaluated by general observation,radiography,histology and image analysis. The new bone areas were calculated by using ANOVA. Results：At 2,4,8,12 weeks,X-ray showed that the regenerative bone density of Yinyanghuo（Epimedium）group was higher than that of the control group. Histoligical observation showed that the amount and maturity of new bone in Yinyanghuo（Epimedium）group were much more higher than those in control group at each time and the volum of bone trabecula and new blood vessel were more in Yinyanghuo（Epimedium）group than in the control group. The new bone area was calculated by using ANOVA and futher multiple comparisons and the final result indicated that there was obvious significance difference in each group. Conclusion：Yinyanghuo（Epimedium）can effectively accelerate the formation and maturity of new bone for mandibular defect through increasing osteogenic gene expression.

关 键 词：淫羊藿 颌骨缺损 骨修复 

分 类 号：R782.4[医药卫生—口腔医学]