健脾祛湿颗粒剂中挥发油β-环糊精包合工艺研究  

Study on Inclusion Process of β-Cyclodextrin of Volatile Oil in Jianpi Qushi Granule

作　　者：田禾[1] 冯程[2] 张伯锋[2] 陈嫚嫚[2] 张学顺[3] 

机构地区：[1]山东中医药大学,山东济南250355 [2]济南市中医医院,山东济南250012 [3]山东中医药大学附属医院,山东济南250012

出　　处：《辽宁中医药大学学报》2015年第3期46-49,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：济南市科技发展计划重点项目(201302030)

摘　　要：目的:筛选健脾祛湿颗粒剂中挥发油的最佳包合工艺。方法:以挥发油转化率、包合物收率为指标,采用β-环糊精(β-CD)饱和水溶液法对挥发油进行了包合,通过正交试验探讨了包合的最佳工艺。结果:包合的最佳工艺为β-CD与挥发油的配比(g∶mL)为10∶1;包合时间为60min,包合温度为40℃,此条件下β-CD包合物的综合评分为77.34分。结论:此包合工艺提高了健脾祛湿颗粒剂中挥发油的利用率。Objective：To optimize the optimal β-cyclodextrin inclusion process of volatile oil. Methods：With the conversione rate of volatile oil and the yield of inclusion as the evaluation indicators,we used the β-cyclodextrin（β-CD）saturated water solution method for the inclusion of volatile oil and investigated the optimal inclusion through the orthogonal test. Results：The optimal prepa-ration conditions for inclusion were established as oil∶β-CD was 1∶10 and the inclusion temperature was 40 ℃ and the duration was for 60min. The comprehensive score of β-CD inclusion complex was 77.34 in this condition. Conclusion：The inclusion process improves the utilization ratio of volatile oils of Jianpi Qushi granule.

关 键 词：健脾祛湿颗粒剂 挥发油 Β-环糊精 正交试验 包合工艺 

分 类 号：R284[医药卫生—中药学]