2013年某院原发性胃癌住院化疗患者用药分析  

Analysis of chemotherapy drug the primary gastric cancerpatient of a hospital inpatient in 2013

作　　者：马欢杰 连海峰[2] 

机构地区：[1]浙江省诸暨市人民医院门诊西药房,浙江诸暨311800 [2]滨州医学院附属医院消化内科,山东滨州256603

出　　处：《中国现代医生》2015年第5期104-107,共4页China Modern Doctor

基　　金：山东省高校科技计划(J11LF75)

摘　　要：目的评价我院原发性胃癌住院化疗患者用药情况。方法回顾性分析2013年1-12月诸暨市人民医院住院化疗的原发性胃癌患者化疗方案、抗肿瘤药品种、辅助用药品种、用药频度（DDDs）、单疗程金额、药物利用指数（DUI）、日均金额等数据资料。结果新辅助化疗主要有4种化疗方案,其中以FOLFOX和ECF方案最多,DCF平均单疗程金额最高;晚期胃癌非手术治疗单纯化疗主要有8种化疗方案,其中改良FOLFOX和FOLFOX最多,CPT-11单用平均单疗程金额最高;术后辅助化疗主要有4种化疗方案,其中XELOX和FOLFOX方案最多,XELOX方案平均单疗程金额最高。主要的抗肿瘤药物有11种,奥沙利铂的使用例次和DDDs均最高,奥沙利铂、5-氟尿嘧啶、表柔比星、替吉奥的DUI均略〉1,卡培他滨、伊立替康、奥沙利铂、多西他赛、替吉奥日均金额较高。抗肿瘤辅助药物主要包括营养支持药物、免疫增强药物、止吐药、保肝药、促白细胞药及中成药。结论住院化疗的原发性胃癌化疗方案呈现多样化,抗肿瘤药物和辅助药物用药合理性尚可,仍存在部分过度用药的情况,应密切结合病情和用药规范改进。Objective To evaluate the gastric cancer patients received chemotherapy medications. Methods A retrospective analysis of patients with primary chemotherapy in our hospital of chemotherapy in gastric cancer from January to December 2013, anticancer varieties, adjuvant varieties, DDDs（DDDs）, the amount of a single course of treatment,drugs utilization index（DUI）, the average daily amount and other data. Results Neoadjuvant chemotherapy were mainly four kinds of chemotherapy, with a maximum of FOLFOX and ECF program,DCF average maximum amount of a single course; non-surgical treatment of advanced gastric cancer chemotherapy alone there were eight kinds of chemotherapy regimens,included FOLFOX and FOLFOX improved the most,CPT-11 single with average maximum amount of a single course; adjuvant chemotherapy are mainly four kinds of chemotherapy regimens, including a maximum of XELOX and FOLFOX regimen,XELOX scheme the maximum amount of the average single course of treatment. The main anticancer drugs have 11 kinds,oxaliplatin use cases and DDDs were the highest,oxaliplatin,5-fluorouracil,epirubicin,Gio＇s DUI were slightly 〉1, capecitabine, irinotecan, oxaliplatin, docetaxel, Gio higher average daily amount. Antitumor drugs included nutritional support auxiliary drugs, immune-enhancing drugs, antiemetics, liver medicine, drugs and medicine to promote WBC. Conclusion Primary chemotherapy in gastric cancer chemotherapy hospitalized diversified, antineoplastic drugs in rationality and auxiliary still remains the case part of the existence of excessive medication, illness and medication should be closely combined with improved specifications.

关 键 词：原发性胃癌 抗肿瘤药物 用药频度 药物利用指数 合理用药 

分 类 号：R735.2[医药卫生—肿瘤]