急性脑出血患者血浆N端脑钠肽前体、和肽素的检测及其临床意义  

Clinical significance and the expression of NT-proBNP and copeptin in patients with acute cerebral hemorrhage

作　　者：杨永凯[1] 张帆[1] 薛少华[1] 何祥中[1] 高伟[1] 刘盾[1] 周晓辉[1] 

机构地区：[1]福建医科大学附属福州市第一医院神经外科,福州350009

出　　处：《重庆医学》2015年第7期910-912,共3页Chongqing medicine

基　　金：福州市科技计划基金资助项目(2012-S-154-5)

摘　　要：目的探讨急性脑出血患者血浆N端脑钠肽前体(NT-proBNP)及和肽素与病情严重程度及脑出血量之间的关系。方法选取该院2011年12月至2013年6月期间诊断为急性脑出血患者109例(脑出血组)和同期体检的健康者32例(对照组),对脑出血组患者和对照组健康者血浆NT-proBNP、和肽素水平与格拉斯哥昏迷评分(GCS)进行比较。结果脑出血组血浆NT-proBNP及和肽素水平明显高于对照组,随病情严重程度及出血量增加呈显著升高,差异有统计学意义(P<0.05)。血浆NTproBNP、和肽素水平与脑出血量呈正相关(r=0.63,r=0.58,P<0.01),与GCS呈负相关(r=-0.52,r=-0.46,P<0.01)。结论血浆NT-proBNP、和肽素水平和急性脑出血关系密切,能反映急性脑出血患者病情严重程度。Objective To investigate the relationship of plasma concentration of NT proBNP,copeptin and glasgow coma scale（GCS） scores,hematoma volumes in patients with acute cerebral hemorrhage. Methods 109 patients with acute cerebral hem- orrhage（the cerebral hemorrhage group）and 32 healthy individuals （the control group） admitted in our hospital from December 2011 to June 2013 were selected and detected for plasma NT-proBNP and copeptin. The levels of NT-proBNP, copeptin, glasgow co- ma scale（GCS） scores and hematoma volumes were compared between the two groups. Results The levels of plasma NT-proBNP and copeptin in the cerebral hemorrhage group were significantly higher than that in control group（P〈0.05）. The levels of plasma NT-proBNP and copeptin were significantly increased with the severity and the hematoma volume of the acute cerebral hemorrhage. The levels of NT-proBNP and copeptin are positively correlated with hematoma volumes（r= 0.63, r= 0.58, P〈0.01）and negative ly correlated with Glasgow Coma Scale（GCS） scores（r= -0.52 ,r= -0.46 ,P〈0.01）. Conclusion The levels of NT-proBNP and copeptin are positively correlated with hematoma volumes and negatively correlated with glasgow coma scale（GCS） scores. They are important clinical parameters to reflect the severity and hematoma volumes of the acute cerebral hemorrhage.

关 键 词：急性脑出血 N端脑钠肽前体 和肽素 GCS评分 脑出血量 

分 类 号：R743.34[医药卫生—神经病学与精神病学]