癸酸对高脂肪饲料喂养的C57BL/6J小鼠降体质量的作用（英文）  

Capric Acid Reduces Body Weight in C57BL/6J Mice Fed a High Fat Diet

作　　者：刘英华[1] 张永[1] 徐庆[1] 张新胜[1] 王觐[1] 于晓明[1] 杨雪艳[1] 薛长勇 

机构地区：[1]解放军总医院营养科,北京100853

出　　处：《营养学报》2014年第6期603-607,I0007,共6页Acta Nutrimenta Sinica

基　　金：partially supported by the Natural Science Foundation of China (No. 81172667, 81202203)

摘　　要：目的研究中链脂肪酸(MCFA)中辛酸或癸酸(C10:0)对体质量的影响及机制。方法高脂肪饲料喂养C57BL/6J小鼠,建立肥胖小鼠模型,随机分为3组,在高脂饲料基础上分别添加2%辛酸(C8:0),2%癸酸(C10:0),或2%油酸(C18:1)。每周监测两次体质量和饲料消耗量。8 w后,测体质量、体脂肪重及与脂解作用相关基因在白色脂肪组织(WAT)中蛋白和m RNA表达。结果癸酸(C10:0)组体重,Lee’s指数,BMI和附睾周围脂肪组织重量显著低于油酸(C18:1)组,WAT中脂肪甘油三酯脂肪酶(ATGL),激素敏感脂肪酶(HSL),环磷酸腺苷(c AMP)和β3肾上腺素能受体(β3-AR)水平显著高于油酸(C18:1)组。辛酸(C8:0)与油酸(C18:1)组比较,均无显著性差异。结论 MCFA的癸酸(C10:0),而不是辛酸(C8:0),可以有效地减少肥胖小鼠体质量,机制可能是上调了WAT中的β3-AR,ATGL和HSL表达,促进了脂解作用。Objective To compare the body weight reducing effect of two medium-chain fatty acids （MCFA）, capric acid and caprylic acid, and the potential underlying mechanisms in C57BL/6J mice fed a high fat diet. Methods Obese C57BL/6J mice were developed on a high-fat diet containing 2% caprylic acid （C8：0）, 2% capric acid （C10：0）, or 2% oleic acid （C18：1）. Body weight and diet intake were monitored twice a week. After 8 weeks of feeding, body fat composition and the protein or mRNA expression of lipolysis-related genes in the white adipose tissue （WAT） were analyzed. Results In the capric acid group, significant reductions were observed in body weight gain, Lee＇s index, BMI, and epididymal adipose tissue weight, while increased levels of adipose triglyceride lipase （ATGL）, hormone-sensitive lipase （HSL）, cyclic adenosine monophosphate （cAMP） and beta 3 adrenergic receptor （133-AR） were found in the adipose tissue, compared to the oleic acid group. No significant differences in these parameters were found between caprylic acid and oleic acid groups. Conclusion Capric acid, but not caprylic acid, is effective in reducing body weight in obese C57BL/6J mice, possibly due to up-regulation of β3-AR, ATGL, and HSL in WAT.

关 键 词：中链脂肪酸 辛酸 癸酸 肥胖 脂解作用 

分 类 号：R589.2[医药卫生—内分泌]